Evidence map›Paper›PMID 40079188›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2025

Investigation of structural and dynamic properties of the Butyrophilin BTN3A1/BTN2A1 cytoplasmic complex by

Khiem Nguyen, Chia-Hung Christine Hsiao, Yiming Jin, Andrew J Wiemer, Olga Vinogradova

Abstract read
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In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Khiem NguyenDepartment of Pharmaceutical Sciences, University of Connecticut, Storrs, Connecticut, USA.ORCID https://orcid.org/0000-0002-6561-4826
Chia-Hung Christine HsiaoDepartment of Pharmaceutical Sciences, University of Connecticut, Storrs, Connecticut, USA.ORCID https://orcid.org/0000-0002-9037-027X
Yiming JinDepartment of Pharmaceutical Sciences, University of Connecticut, Storrs, Connecticut, USA.ORCID https://orcid.org/0000-0001-6151-7327
Andrew J WiemerDepartment of Pharmaceutical Sciences, University of Connecticut, Storrs, Connecticut, USA.ORCID https://orcid.org/0000-0002-3029-1780
Olga VinogradovaDepartment of Pharmaceutical Sciences, University of Connecticut, Storrs, Connecticut, USA.ORCID https://orcid.org/0000-0001-5101-7361

Funding

Role of immune modulating butyrophilins in gamma delta T cell activationR01AI150869 · NIAID · UNIVERSITY OF CONNECTICUT STORRS · PI VINOGRADOVA, OLGA, WIEMER, ANDREW J · 2020 to 2024
$2.0M
HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI150869NIAID NIH HHS R01 AI150869
6 · The paper itself

Abstract

Butyrophilin 3A1 (BTN3A1) is an integral membrane protein capable of detecting phosphoantigens, like (E)-4-hydroxy-3-methyl-but-2-enyl diphosphate (HMBPP), through its internal B30.2 domain. Detection of phosphoantigens leads to interactions with butyrophilin 2A1 and the subsequent activation of γδ-T cells. Though crystallography and functional assays have been crucial for determining vital residues of the BTN3A1/HMBPP/BTN2A1 complex, the mechanism for signal transduction is still unclear. Here, we utilize

Indexed as

Antigens, CDButyrophilinsCytoplasmHumansMagnetic Resonance SpectroscopyNuclear Magnetic Resonance, BiomolecularProtein BindingProtein ConformationAntigens, CDBTN3A1 protein, humanButyrophilinsbutyrophilin 2A1butyrophilin 3A1ButyrophilinsfluorineHMBPPnuclear magnetic resonancephosphoantigenprotein conformation

Identifiers

PMID40079188
PMCPMC11908674

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.