ArticleInternational journal of cosmetic science2025
Protective effects of Paeonia suffruticosa callus extract in skin through anti-inflammation and repair UVB-induced damage.
Article in International journal of cosmetic science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
3 citing papers in PubMed.
- Paeonol as a Multi-Target Therapy for Neurological Disorders: Mechanistic Insights Into Neuroprotection.Immunity, inflammation and disease · 2026Review
- Characterization ofInternational journal of molecular sciences · 2026Article
- Protective effects of Paeonia suffruticosa callus extract in skin through anti-inflammation and repair UVB-induced damage.International journal of cosmetic science · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe study investigated effects of peony callus extracts (PCE) on the protective efficacy against Ultraviolet B (UVB)-induced photoageing, using in vitro and in vivo studies. The research focused on PCE's ability to protect against inflammatory factors, DNA damage and accumulation of senescent cells, along with the evaluation of the extract's potential anti-photoageing benefits to skin.
methodsHuman keratinocyte cell line (HaCaT cells), mast cells and fibroblasts were used to evaluate the role of PCE in anti-photoageing. The expression of genes of interleukin-1α (IL-1α), IL-6 and transient receptor potential vanilloid 1 (TRPV1) were tested in HaCaT cells. The histamine contents in mast cells were tested to evaluate the effect of PCE on soothing skin. Additionally, the repairment of PCE on DNA damage stimulated by UVB using comet assay was evaluated. In fibroblasts, the gene expression of matrix metalloproteinases (MMPs) and the activity of β-galactosidase were tested. In vivo test, 13 healthy volunteers were enrolled to apply a formula with 1% PCE to assess the variation in inner skin collagen contents.
resultsThe callus from an ancient and rare variety of tree peony (Paeoniaceae family) was successfully induced, and its ingredients were extracted. The PCE could significantly downregulate inflammation factors such as IL-1α, IL-6 and TRPV1 in HaCaT cells, and MMPs in fibroblasts which could cause the collagen degradation induced by UVB. Meanwhile, UVB-induced DNA damage was alleviated by PCE. The analysis of histamine content in mast cells revealed that PCE effectively alleviated skin sensitivity. Furthermore, the clinical trials validated a significant increase in total collagen content in vivo, following 28 days of continuous application of a cosmetic formulation containing 1% PCE measured by Raman confocal spectroscopy technology.
conclusionThe PCE could downregulate the gene expression of inflammatory factors, indicating the ability of DNA repair. The number of senescent cells was also decreased after UVB stimulation. Furthermore, the results of in vivo study showed that PCE was an ideal cosmetic ingredient for promoting collagen levels.
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