Evidence map›Paper›PMID 40079161›Full record

ArticleAddiction (Abingdon, England)2025

Medication experiences in the treatment of opioid use disorders: Insights from Reddit.

Alexandra Almeida, Mike Conway, David J Grelotti, Amarnath Gupta, David Frank, Annick Bórquez

Abstract read
In one paragraph

Article in Addiction (Abingdon, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Alexandra AlmeidaScientific Computing Program, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.ORCID https://orcid.org/0000-0003-2092-5070
Mike ConwayCentre for Digital Transformation of Health, University of Melbourne, Carlton, Australia.
David J GrelottiDepartment of Psychiatry, UC San Diego School of Medicine, San Diego, CA, USA.
Amarnath GuptaSan Diego Supercomputer Center, University of California San Diego, La Jolla, CA, USA.
David FrankDepartment of Social and Behavioral Sciences and Center for Drug Use and HIV/HCV Research, School of Global Public Health, New York University, New York, NY, USA.
Annick BórquezDivision of Infectious Diseases and Global Public Health, University of California San Diego, San Diego, CA, USA.ORCID https://orcid.org/0000-0002-6033-9837

Funding

VirologyP30AI036214 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SUSAN JANET LITTLE · 1994 to 2026
$78.4M
Real-time prediction of emerging drug use epidemics in the United StatesDP2DA049295 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BORQUEZ, ANNICK · 2019 to 2019
$2.4M
NIAID NIH HHS P30 AI036214NIDA NIH HHS DP2 DA049295NIDA NIH HHS DP2DA049295
6 · The paper itself

Abstract

BACKGROUND AND

aimsBetter understanding the challenges faced by patients on medications for opioid use disorder (MOUD), including methadone and buprenorphine, is critical to increasing their use/retention. Social media platforms such as Reddit offer a space for patients to share their experiences with medications. We aimed to identify and characterize challenges faced by patients taking MOUD through analysis of discussions from the r/Methadone and r/suboxone subreddits. DESIGN, SETTING AND

participantsMixed methods study applying natural language processing methods to 37 278 posts from both subreddits from their origin in 2011 until 31 December 2022. Independent topic analyses used Correlated Topic Models to extract the main themes discussed. MEASUREMENTS: We labeled, validated and grouped the topics into macro classes and computed topic shares. We interpreted and compared topics across subreddits informed by the patient-centered medication experience framework.

findingsWe found 27 and 34 challenge-related topics for the r/Methadone and r/suboxone subreddits, respectively. Topics were grouped into three macro-topics: (i) healthcare-related issues, including misunderstandings/confusion around appointments, prescriptions, bottle checks, telehealth technology and health insurance coverage; (ii) medication-related issues, including withdrawal, cravings, dosage, side effects, mixing with other medications/drugs; and (iii) treatment discontinuation, including tapering protocols. Patients conveyed highly specialized knowledge about dosage and tapering strategies and spoke from experience. Key differences between r/Methadone and r/suboxone were driven by their dispensing requirements (clinic-based vs. take-home), with 20.05% vs 14.74% of posts related to healthcare service, primarily for logistic and interpersonal issues with healthcare providers.

conclusionPeople who post on the r/Methadone and r/suboxone subreddits appear to have detailed knowledge of medications for opioid use disorder and want more control over their dosing, effects, side effects and discontinuation. Acknowledging this expertise and establishing stronger patients' partnerships with the healthcare team and system might result in better treatment outcomes.

Indexed as

Analgesics, OpioidBuprenorphineMethadoneOpiate Substitution TreatmentOpioid-Related DisordersSocial MediaHumansAnalgesics, OpioidBuprenorphineMethadoneinfodemiologymedication experienceMOUDNLPopioidsreddit

Identifiers

PMID40079161
PMCPMC12215240

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.