ArticleArteriosclerosis, thrombosis, and vascular biology2025
Murine Aortic Valve Cell Heterogeneity at Birth.
Article in Arteriosclerosis, thrombosis, and vascular biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- Immune Mechanisms of Heart Valve Development, Homeostasis, and Disease.Arteriosclerosis, thrombosis, and vascular biology · 2026Review
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Authors and funding
5 authors.
Funding
Abstract
backgroundHeart valve function requires a highly organized ECM (extracellular matrix) network that provides the necessary biomechanical properties needed to withstand pressure changes during each cardiac cycle. Lay down of the valve ECM begins during embryogenesis and continues throughout postnatal stages when it is remodeled into stratified layers and arranged according to blood flow. Alterations in this process can lead to dysfunction and, if left untreated, heart failure. Despite this, the mechanisms that establish structure-function relationships of the valve, particularly during postnatal maturation, are poorly understood.
methodsTo address this, single-cell transcriptomics was performed on murine aortic valve structures at postnatal day 1.
resultsOverall, 18 clusters of 7 diverse cell populations were identified, including a novel valve endothelial cell subpopulation unique to postnatal day 1 and 3 previously unappreciated valve interstitial cell subpopulations defined as primitive, remodeling, and bioactive. Additional lineage tracing of the primitive valve interstitial cell subpopulation in mice uncovered a temporal and spatial trajectory throughout postnatal maturation.
conclusionsIn summary, this work highlights the heterogeneity of cell types within the aortic valve structure at birth that contribute to establishing and maintaining structure and function throughout life.
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