Evidence map›Paper›PMID 40079121›Full record

ArticleCirculation. Cardiovascular imaging2025

Differences in Pulmonary Artery Stiffness Measured by CMR in Preterm-Born Young Adults With and Without Bronchopulmonary Dysplasia.

Wouter J van Genuchten, Jarno J Steenhorst, Gabrielle M J W van Tussenbroek, Nikki van der Velde, Lieke S Kamphuis, Irwin K M Reiss, Daphne Merkus, Willem A Helbing, Alexander Hirsch

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation. Cardiovascular imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Wouter J van Genuchten *Division of Pediatric Cardiology, Department of Pediatrics, Cardiovascular Institute, Erasmus MC, Rotterdam, The Netherlands (W.J.v.G., J.J.S., G.M.J.W.v.T., W.A.H.).
Jarno J Steenhorst *Division of Pediatric Cardiology, Department of Pediatrics, Cardiovascular Institute, Erasmus MC, Rotterdam, The Netherlands (W.J.v.G., J.J.S., G.M.J.W.v.T., W.A.H.).ORCID 0000-0002-1998-181X
Gabrielle M J W van TussenbroekDivision of Pediatric Cardiology, Department of Pediatrics, Cardiovascular Institute, Erasmus MC, Rotterdam, The Netherlands (W.J.v.G., J.J.S., G.M.J.W.v.T., W.A.H.).
Nikki van der VeldeDepartment of Cardiology, Cardiovascular Institute, Thorax Center, Erasmus MC, Rotterdam, The Netherlands (J.J.S., N.v.d.V., D.M., A.H.).ORCID 0000-0003-2678-8521
Lieke S KamphuisDepartment of Pulmonology (L.S.K.), Erasmus MC, Rotterdam, The Netherlands.
Irwin K M ReissDivision of Neonatology, Department of Neonatal and Pediatric Intensive Care (I.K.M.R.), Erasmus MC, Rotterdam, The Netherlands.ORCID 0000-0002-9474-6895
Daphne MerkusDepartment of Cardiology, Cardiovascular Institute, Thorax Center, Erasmus MC, Rotterdam, The Netherlands (J.J.S., N.v.d.V., D.M., A.H.).ORCID 0000-0002-4852-831X
Willem A HelbingDivision of Pediatric Cardiology, Department of Pediatrics, Cardiovascular Institute, Erasmus MC, Rotterdam, The Netherlands (W.J.v.G., J.J.S., G.M.J.W.v.T., W.A.H.).ORCID 0000-0002-1023-1537
Alexander HirschDepartment of Cardiology, Cardiovascular Institute, Thorax Center, Erasmus MC, Rotterdam, The Netherlands (J.J.S., N.v.d.V., D.M., A.H.).ORCID 0000-0002-3315-2006

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundVery preterm-born infants are at risk for developing bronchopulmonary dysplasia (BPD), a chronic lung disease. Nowadays, the majority of these infants reach adulthood. Very preterm-born young adults are at risk for developing pulmonary arterial (PA) hypertension later in life. An early sign of PA hypertension is increased PA stiffness. This study aims to use cardiovascular magnetic resonance to compare PA stiffness using PA relative area change (RAC) and pulse wave velocity (PWV) to identify early signs for PA hypertension in young adults born very premature, with and without BPD.

methodsTwenty preterm-born young adults with and 20 without BPD underwent cardiovascular magnetic resonance and were compared with 20 at-term-born young adults. RAC was calculated as the percentage change between the maximal and minimal areas of the PA. PWV was calculated using a method that simultaneously compares flow and area increase in the pulmonary artery during early systole.

resultsIn 57 of 60 patients, PWV and RAC measurements could be performed. Preterm-born young adults with BPD showed increased PWV compared with preterm-born young adults without BPD (median [25th-75th percentile] 2.07 m/s [1.45-3.05] versus 1.61 m/s [1.18-1.85];

conclusionsPreterm-born young adults with BPD show increased PA stiffness as measured by PWV compared with preterm-born young adults without BPD and at-term-born young adults; RAC was decreased in both preterm-born groups compared with at-term controls. This noninvasive method of measuring PA stiffness might be a valuable tool to identify individuals at risk for early signs of PA hypertension in this population.

Indexed as

Bronchopulmonary DysplasiaMagnetic Resonance Imaging, CinePulmonary ArteryVascular StiffnessAdultFemaleGestational AgeHumansInfant, NewbornInfant, PrematureMalePredictive Value of TestsPulse Wave AnalysisYoung Adultbronchopulmonary dysplasiamagnetic resonance imagingpreterm infantspulmonary arterial hypertensionpulmonary artery

Identifiers

PMID40079121
PMCPMC12005864

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.