Evidence map›Paper›PMID 40078995›Full record

ReviewFrontiers in immunology2025

The multi-faceted immune modulatory role of S100A4 in cancer and chronic inflammatory disease.

Thomas Wong, Reece Kang, Kyuson Yun

Abstract readReview
In one paragraph

Review in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Review
  2. Article
  3. S100A4 Orchestrates Fibroblast Fate to Drive Fibrotic Remodeling.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Observational
  11. Article
  12. Review
  13. Review
  14. Article
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Thomas WongDepartment of Neurology, Houston Methodist Research Institute, Houston, TX, United States.
Reece KangDepartment of Neurology, Houston Methodist Research Institute, Houston, TX, United States.
Kyuson YunDepartment of Neurology, Houston Methodist Research Institute, Houston, TX, United States.

Funding

S100A4 mediated immune suppression in GBMR01NS121405 · NINDS · METHODIST HOSPITAL RESEARCH INSTITUTE · PI YUN, KYUSON · 2021 to 2025
$2.2M
NINDS NIH HHS R01 NS121405
6 · The paper itself

Abstract

S100A4 is a Ca

Indexed as

InflammationNeoplasmsS100 Calcium-Binding Protein A4AnimalsChronic DiseaseHumansS100A4 protein, humanS100 Calcium-Binding Protein A4cancerchronic inflammationfibrosisFSP-1immune suppressionmacrophagesS100A4T cells

Identifiers

PMID40078995
PMCPMC11897520

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.