ArticleJournal of medical imaging (Bellingham, Wash.)2025
Impact of menopause and age on breast density and background parenchymal enhancement in dynamic contrast-enhanced magnetic resonance imaging.
Article in Journal of medical imaging (Bellingham, Wash.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- ABUS-based glandular tissue component classification for breast cancer risk prediction in Chinese women with dense breasts: a retrospective study.BMC medical imaging · 2026Article
- Comparison of Contralateral Breast Background Parenchymal Enhancement on MRI Before and After Neoadjuvant Chemotherapy According to Molecular Subtypes in Unilateral Breast Cancer.Diagnostics (Basel, Switzerland) · 2025Article
- Introduction to the JMI Special Issue on Advances in Breast Imaging.Journal of medical imaging (Bellingham, Wash.) · 2025Article
- Determinants of Background Parenchymal Enhancement on breast MRI.Current health sciences journalArticle
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5 authors.
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Abstract
Purpose: Breast density (BD) and background parenchymal enhancement (BPE) are important imaging biomarkers for breast cancer (BC) risk. We aim to evaluate longitudinal changes in quantitative BD and BPE in high-risk women undergoing dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI), focusing on the effects of age and transition into menopause. Approach: A retrospective cohort study analyzed 834 high-risk women undergoing breast DCE-MRI for screening between 2005 and 2020. Quantitative BD and BPE were derived using deep-learning segmentation. Linear mixed-effects models assessed longitudinal changes and the effects of age, menopausal status, weeks since the last menstrual period (LMP-wks), body mass index (BMI), and hormone replacement therapy (HRT) on these imaging biomarkers. Results: BD decreased with age across all menopausal stages, whereas BPE declined with age in postmenopausal women but remained stable in premenopausal women. HRT elevated BPE in postmenopausal women. Perimenopausal women exhibited decreases in both BD and BPE during the menopausal transition, though cross-sectional age at menopause had no significant effect on either measure. Fibroglandular tissue was positively associated with BPE in perimenopausal women. Conclusions: We highlight the dynamic impact of menopause on BD and BPE and correlate well with the known relationship between risk and age at menopause. These findings advance the understanding of imaging biomarkers in high-risk populations and may contribute to the development of improved risk assessment leading to personalized chemoprevention and BC screening recommendations.
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