ArticleLife metabolism2025
Circulating short-chain and branched short-chain fatty acids and the risk of incident type 2 diabetes: findings from the 4C study.
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Article in Life metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
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5 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Changes in short-chain fatty acids across the glycemic spectrum: a systematic review and meta-analysis.Frontiers in public health · 2026Pooled it
- Gut microbiota and fecal 2-methylbutyric acid in coronary heart disease: a cross-sectional study.Scientific reports · 2026Article
- Distinct patterns and interactions of microbiota and short-chain fatty acids in breast milk and infant gut from rural and urban dyads.Frontiers in microbiology · 2026Article
- From Brewery Waste to Sustainable Aquafeed: HarnessingAquaculture nutrition · 2026Article
- Bile Acids and Type 2 Diabetes: Roles in Glucose Homeostasis and Therapeutic Opportunities.Metabolites · 2025Review
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57 authors.
Shuangyuan WangDepartment of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Hong LinDepartment of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Xiaojing JiaDepartment of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Yiting LinDepartment of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Chunyan HuDepartment of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Mian LiDepartment of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Yu XuDepartment of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Min XuDepartment of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.ORCID https://orcid.org/0000-0003-3930-8718
Jie ZhengDepartment of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.ORCID https://orcid.org/0000-0002-4265-6695
Xinjie ZhaoKey Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, Liaoning 116023, China.
Yanli LiKey Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, Liaoning 116023, China.
Lulu ChenDepartment of Endocrine and Metabolic Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, China.
Tianshu ZengDepartment of Endocrine and Metabolic Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, China.
Ruying HuZhejiang Provincial Center for Disease Control and Prevention, Hangzhou, Zhejiang 310051, China.
Zhen YeZhejiang Provincial Center for Disease Control and Prevention, Hangzhou, Zhejiang 310051, China.
Lixin ShiDepartment of Endocrine and Metabolic Diseases, Affiliated Hospital of Guiyang Medical College, Guiyang, Guizhou 550004, China.
Qing SuDepartment of Endocrine and Metabolic Diseases, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China.
Yuhong ChenDepartment of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Xuefeng YuDepartment of Endocrine and Metabolic Diseases, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.
Li YanDepartment of Endocrine and Metabolic Diseases, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510120, China.
Tiange WangDepartment of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.ORCID https://orcid.org/0000-0003-0723-489X
Zhiyun ZhaoDepartment of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Guijun QinDepartment of Endocrine and Metabolic Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China.ORCID https://orcid.org/0000-0002-2503-7534
Qin WanDepartment of Endocrine and Metabolic Diseases, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, China.
Gang ChenDepartment of Endocrine and Metabolic Diseases, Fujian Provincial Hospital, Fujian Medical University, Fuzhou, Fujian 350003, China.
Meng DaiDepartment of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Di ZhangDepartment of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Bihan QiuDepartment of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Xiaoyan ZhuDepartment of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Ruixin LiuDepartment of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.ORCID https://orcid.org/0000-0002-5526-6717
Xiao WangDepartment of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Xulei TangDepartment of Endocrine and Metabolic Diseases, The First Hospital of Lanzhou University, Lanzhou, Gansu 730000, China.
Zhengnan GaoDepartment of Endocrine and Metabolic Diseases, Dalian Municipal Central Hospital, Dalian, Liaoning 116033, China.
Feixia ShenDepartment of Endocrine and Metabolic Diseases, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China.
Xuejiang GuDepartment of Endocrine and Metabolic Diseases, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China.
Zuojie LuoDepartment of Endocrine and Metabolic Diseases, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, China.
Yingfen QinDepartment of Endocrine and Metabolic Diseases, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, China.
Li ChenDepartment of Endocrine and Metabolic Diseases, Qilu Hospital of Shandong University, Jinan, Shandong 250012, China.
Xinguo HouDepartment of Endocrine and Metabolic Diseases, Qilu Hospital of Shandong University, Jinan, Shandong 250012, China.
Yanan HuoDepartment of Endocrine and Metabolic Diseases, Jiangxi Provincial People's Hospital Affiliated to Nanchang University, Nanchang, Jiangxi 330006, China.
Qiang LiDepartment of Endocrine and Metabolic Diseases, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150086, China.
Guixia WangDepartment of Endocrine and Metabolic Diseases, The First Hospital of Jilin University, Changchun, Jilin 130021, China.
Yinfei ZhangDepartment of Endocrine and Metabolic Diseases, Central Hospital of Shanghai Jiading District, Shanghai 201800, China.
Chao LiuDepartment of Endocrine and Metabolic Diseases, Jiangsu Province Hospital on Integration of Chinese and Western Medicine, Nanjing, Jiangsu 210028, China.
Youmin WangDepartment of Endocrine and Metabolic Diseases, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, China.
Shengli WuDepartment of Endocrine and Metabolic Diseases, Karamay Municipal People's Hospital, Karamay, Xinjiang 834000, China.
Tao YangDepartment of Endocrine and Metabolic Diseases, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China.ORCID https://orcid.org/0000-0001-6375-3622
Huacong DengDepartment of Endocrine and Metabolic Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Jiajun ZhaoDepartment of Endocrine and Metabolic Diseases, Shandong Provincial Hospital affiliated to Shandong University, Jinan, Shandong 250021, China.ORCID https://orcid.org/0000-0003-3267-9292
Yiming MuDepartment of Endocrine and Metabolic Diseases, Chinese People's Liberation Army General Hospital, Beijing 100853, China.
Guowang XuKey Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, Liaoning 116023, China.ORCID https://orcid.org/0000-0003-4298-3554
Shenghan LaiDepartment of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD 21201, United States.
Donghui LiDepartment of Gastrointestinal Medical Oncology, the University of Texas MD Anderson Cancer Center, Houston, TX 77030, United States.ORCID https://orcid.org/0000-0002-7542-0662
Guang NingDepartment of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.ORCID https://orcid.org/0000-0002-5754-7635
Weiqing WangDepartment of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.ORCID https://orcid.org/0000-0001-6027-3084
Yufang BiDepartment of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Jieli LuDepartment of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.ORCID https://orcid.org/0000-0003-1317-0896
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous studies suggested that fecal short-chain fatty acids (SCFAs) and branched short-chain fatty acids (BCFAs) are associated with glucose regulation. However, the potential relationship between circulating SCFAs and BCFAs with incident diabetes risk in both men and women remains unidentified in prospective cohort studies. In this study, we examined a panel of nine serum SCFAs and BCFAs in 3414 subjects with incident diabetes, and matched normoglycemic controls from the China Cardiometabolic Disease and Cancer Cohort study. In fully adjusted conditional logistic regression models, total SCFAs, total BCFAs, and isovaleric acid were significantly associated with incident type 2 diabetes mellitus (T2DM) (
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branched short-chain fatty acidsinsulin resistanceshort-chain fatty acidstype 2 diabetes
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