ReviewFrontiers in bioengineering and biotechnology2025
The rational design, biofunctionalization and biological properties of orthopedic porous titanium implants: a review.
Review in Frontiers in bioengineering and biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- Porous Ti-6Al-4V Architectures in Load-Bearing Orthopedic Reconstruction: A Critical Narrative Review of the Translational Gap Across Microstructure, Fatigue, Surface Function, and Clinical Failure Modes.Materials (Basel, Switzerland) · 2026Review
- Titanium Degradation Products from Dental Implants: Mechanisms of Release, Biodistribution, and Analytical Detection in Biological Matrices.International journal of molecular sciences · 2026Review
- Feasibility of Ti-6Al-4V Alloys with Nanoporous and Nanotubular Surfaces for the Treatment of Femoral Defects.International journal of molecular sciences · 2026Article
- Topological optimization synergized with a high-activity nano-hydroxyapatite coating to enhance bone regeneration in a porous titanium alloy scaffold.Regenerative biomaterials · 2026Article
- Novel Clinical Applications of 3D-Printed Highly Porous Titanium for Off-the-Shelf Cementless Joint Replacement Prostheses.Biomimetics (Basel, Switzerland) · 2025Article
- Effect of Ti6Al4V Alloy Surface and Porosity on Bone Osseointegration: In Vivo Pilot Study in Rabbits.Materials (Basel, Switzerland) · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Porous titanium implants are becoming an important tool in orthopedic clinical applications. This review provides a comprehensive survey of recent advances in porous titanium implants for orthopedic use. First, the review briefly describes the characteristics of bone and the design requirements of orthopedic implants. Subsequently, the pore size and structural design of porous titanium alloy materials are presented, then we introduce the application of porous titanium alloy implants in orthopedic clinical practice, including spine surgery, joint surgery, and the treatment of bone tumors. Following that, we describe the surface modifications applied to porous titanium implants to obtain better biological functions. Finally, we discuss incorporating environmental responsive mechanisms into porous titanium alloy materials to achieve additional functionalities.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.