Evidence map›Paper›PMID 40078786›Full record

ReviewImmune network2025

Regulation of Adaptive Immunity by Lipid Post-translational Modifications.

Jonathan R Mattingly, Aimee Wu, Autumn G York

Abstract readReview
In one paragraph

Review in Immune network, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Jonathan R MattinglyDepartment of Immunology, School of Medicine, University of Washington, Seattle, WA 98195, USA.ORCID https://orcid.org/0009-0008-9525-5327
Aimee WuDepartment of Immunology, School of Medicine, University of Washington, Seattle, WA 98195, USA.
Autumn G YorkDepartment of Immunology, School of Medicine, University of Washington, Seattle, WA 98195, USA.ORCID https://orcid.org/0000-0002-0331-043X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The burgeoning field of immunometabolism highlights the interdependence between metabolic programs and efficacious immune responses. The current understanding that cellular metabolic remodeling is necessary for a competent adaptive immune response, along with acutely sensitive methodologies such as high-performance liquid chromatography/mass spectrometry and advanced proteomics, have ushered in a renaissance of lipid- and metabolic-based scientific inquiries. One facet of recent interest examines how lipids function as post-translational modifications (PTMs) and their resulting effects on adaptive immune responses. The goal of this review is to establish a fundamental understanding of these protein modifications and highlight recent findings that underscore the importance of continued investigation into lipids as PTMs.

Indexed as

Adaptive immunityMyristoylationPalmitoylationPrenylation

Identifiers

PMID40078786
PMCPMC11896658

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.