ArticleNpj imaging2024
Real-time tracking of the Bragg peak during proton therapy via 3D protoacoustic Imaging in a clinical scenario.
Article in Npj imaging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed.
- Roadmap for the implementation of particle minibeam therapy.Medical physics · 2026Review
- Shape-optimized Model-based Reconstruction Algorithm for Radiacoustic Imaging.Applied physics letters · 2026Article
- Ionizing radiation acoustic beam localization: one step towards "proton surgery".medRxiv : the preprint server for health sciences · 2026Article
- Seeing the invisible: In vivo dosimetry in radiotherapy with radiacoustic IMAGING.Medical physics · 2025Review
- Bridging Photoacoustic and Protoacoustic Imaging: Material Heterogeneity Effects on Proton Range Verification Using Time-of-Flight Analysis.Bioengineering (Basel, Switzerland) · 2025Article
- Understanding and Exacerbating the Biological Response of Uveal Melanoma to Proton Beam Therapy.Cancers · 2025Review
- Proton Range Measurement Precision in Ionoacoustic Experiments with Wavelet-Based Denoising Algorithm.Sensors (Basel, Switzerland) · 2025Article
- Thermoacoustic range verification during conventional dose rate delivery by a synchrocyclotron.Medical physics · 2025Article
- Monte Carlo simulation of a novel medical linac concept for highly conformal x-ray FLASH cancer radiotherapy.Scientific reports · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Proton radiotherapy favored over X-ray photon therapy due to its reduced radiation exposure to surrounding healthy tissues, is highly dependent on the accurate positioning of the Bragg peak. Existing methods like PET and prompt gamma imaging to localize Bragg peak face challenges of low precision and high complexity. Here we introduce a 3D protoacoustic imaging with a 2D matrix array of 256 ultrasound transducers compatible with 256 parallel data acquisition channels provides real-time imaging capability (up to 75 frames per second with 10 averages), achieving high precision (5 mm/5% Gamma index shows accuracy better than 95.73%) at depths of tens of centimeters. We have successfully implemented this method in liver treatment with 5 pencil beam scanning and in prostate cancer treatment on a human torso phantom using a clinical proton machine. This demonstrates its capability to accurately identify the Bragg peak in practical clinical scenarios. It paves the way for adaptive radiotherapy with real-time feedback, potentially revolutionizing radiotherapy by enabling closed-loop treatment for improved patient outcomes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.