Evidence map›Paper›PMID 40078667›Full record

ArticleBiosafety and health2024

The differential effects of integrase strand transfer inhibitors and efavirenz on neuropsychiatric conditions and brain imaging in HIV-positive men who have sex with men.

Yihui He, Yang Zhang, Jiaxin Zhen, Guangqiang Sun, Zhen Li, Bo Yang, Bin Yang, Keyi Chang, Xue Chen, Yulin Zhang and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biosafety and health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Yihui HePostgraduate Union Training Base of Jinzhou Medical University, PLA Rocket Force Characteristic Medical Center, Beijing 100088, China.
Yang ZhangCenter for Infectious Disease, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China.
Jiaxin ZhenCenter for Infectious Disease, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China.
Guangqiang SunBeijing Key Laboratory of Mental Disorders, National Clinical Research Center for Mental Disorders and National Center for Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing 100088, China.
Zhen LiCenter for Infectious Disease, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China.
Bo YangThe Second Hospital of Beijing, Beijing 100031, China.
Bin YangThe Second Hospital of Beijing, Beijing 100031, China.
Keyi ChangCenter for Infectious Disease, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China.
Xue ChenCenter for Infectious Disease, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China.
Yulin ZhangDepartment of Respiratory and Critical Care Medicine, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China.
Caiping GuoCenter for Infectious Disease, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China.
Wen WangCenter for Infectious Disease, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China.
Ping WuNational Institute on Drug Dependence and Beijing Key Laboratory of Drug Dependence, Peking University, Beijing 100191, China.
Tong ZhangCenter for Infectious Disease, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China.
Lei WangPostgraduate Union Training Base of Jinzhou Medical University, PLA Rocket Force Characteristic Medical Center, Beijing 100088, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Integrase strand transfer inhibitors (INSTIs) have emerged as the first-line choice for treating human immunodeficiency virus (HIV) infection due to their superior efficacy and safety. However, the impact of INSTIs on the development of neuropsychiatric conditions in people living with HIV (PLWH) is not fully understood due to limited data. In this study, we conducted a cross-sectional examination of PLWH receiving antiretroviral therapy, with a specific focus on HIV-positive men who have sex with men (MSM) on INSTI-based regimens (n = 61) and efavirenz (EFV)-based regimens (n = 28). Participants underwent comprehensive neuropsychiatric evaluations and multimodal magnetic resonance imaging (MRI) scans, including T1-weighted images and resting-state functional MRI. Compared to the EFV group, the INSTI group exhibited primarily reduced gray matter volume (GMV) in the right superior parietal gyrus, higher regional homogeneity (ReHo) in the left postcentral gyrus, lower ReHo in the right orbital part of the inferior frontal gyrus, and increased voxel-wise functional connectivity for the seed region in the left inferior temporal gyrus with clusters in the right cuneus. Furthermore, the analysis revealed a main effect of antiretroviral drugs on GMV changes, but no main effect of neuropsychiatric disorders or their interaction. The repeated analysis of participants who did not switch regimens confirmed the GMV changes in the INSTI group, validating the initial findings. Our study demonstrated gray matter atrophy and functional brain changes in PLWH on INSTI-based regimens compared to those on EFV-based regimens. These neuroimaging results provide valuable insights into the characteristics of brain network modifications in PLWH receiving INSTI-based regimens.

Indexed as

Efavirenz (EFV)Human immunodeficiency virus (HIV)Integrase strand transfer inhibitors (INSTIs)Multimodal magnetic resonance imaging (MRI)

Identifiers

PMID40078667
PMCPMC11894960

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.