Evidence map›Paper›PMID 40078539›Full record

ArticleFrontiers in microbiology2025

Internal in-frame translation generates Cas11b, which is important for effective interference in an archaeal CRISPR-Cas system.

A-L Sailer, J Brendel, A Chernev, S König, T Bischler, T Gräfenhan, H Urlaub, U Gophna, A Marchfelder

Abstract read
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In one paragraph

Article in Frontiers in microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

A-L Sailer *Molecular Biology and Biotechnology of Prokaryotes, Ulm University, Ulm, Germany.
J Brendel *Molecular Biology and Biotechnology of Prokaryotes, Ulm University, Ulm, Germany.
A ChernevBioanalytical Mass Spectrometry Group, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.
S KönigBioanalytical Mass Spectrometry Group, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.
T BischlerCore Unit Systems Medicine, University of Würzburg, Würzburg, Germany.
T GräfenhanCore Unit Systems Medicine, University of Würzburg, Würzburg, Germany.
H UrlaubBioanalytical Mass Spectrometry Group, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.
U GophnaThe Shmunis School of Biomedicine and Cancer Research, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel.
A MarchfelderMolecular Biology and Biotechnology of Prokaryotes, Ulm University, Ulm, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

CRISPR-Cas is a sophisticated defence system used by bacteria and archaea to fend off invaders. CRISPR-Cas systems vary in their Cas protein composition and have therefore been divided into different classes and types. Type I systems of bacteria have been shown to contain the small protein Cas11 as part of the interference complex known as Cascade. Here we show for the first time that an archaeal CRISPR-Cas type I-B system also contains a homolog of Cas11. The Cas11b protein, encoded by the

Indexed as

archaeaCas11CRISPR-CasHaloferax volcaniiin-frame translationtype I-B

Identifiers

PMID40078539
PMCPMC11899642

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.