ArticleFrontiers in nutrition2025
Machine learning-driven insights into lipid metabolism and inflammatory pathways in knee osteoarthritis.
Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Endocrine‑metabolic imbalance drives osteoarthritis: From whole‑joint pathobiology to precision therapy (Review).International journal of molecular medicine · 2026Review
- From structural recognition to mechanistic forecasting: repositioning artificial intelligence in osteoarthritis prevention.Frontiers in immunology · 2026Article
- From mechanical triggering to metabolic-inflammatory driving: a new paradigm of knee osteoarthritis pathogenesis.Frontiers in immunology · 2026Review
- Risk factors associated with knee osteoarthritis severity and their correlation with Kellgren-Lawrence grade.Frontiers in medicine · 2025Article
- Association between BMI and knee osteoarthritis in Chinese adults aged 45 years and older: evidence from the 2021 Global Burden of Disease analysis and the China Health and Retirement Longitudinal Study.Frontiers in public health · 2025Article
- The Value of Using 5T MRI T1ρ and T2 Mapping Sequences in Evaluating Muscle Changes Around Knee Osteoarthritis.Dose-response : a publication of International Hormesis SocietyArticle
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Authors and funding
6 authors.
Funding
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Abstract
Knee osteoarthritis (KOA) is a multifactorial degenerative joint disease influenced by lipid metabolism, systemic inflammation, and dietary factors. This study integrates clinical data, biochemical markers, and machine learning models to identify key predictors of KOA severity and develop personalized dietary strategies for disease management. A cohort of 600 KOA patients was analyzed, revealing significant correlations between dyslipidemia (low HDL, high LDL) and inflammatory biomarkers (CRP, IL-6). Machine learning models identified BMI, CRP, and IL-6 as critical predictors of pain severity (AUC = 0.93). Based on these findings, we propose targeted dietary recommendations, including increased omega-3 fatty acid intake and reduced saturated fat consumption, to modulate inflammation and improve clinical outcomes. This study highlights the potential of precision nutrition approaches in addressing the metabolic and inflammatory underpinnings of KOA.
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