Evidence map›Paper›PMID 40078212›Full record

ArticleFrontiers in veterinary science2025

A non-randomized pilot study to test the feasibility of developing a frailty scale for pet cats.

Elizabeth J Colleran, Mikel M Delgado, Yunyi Ren, Alexander J German, Margaret E Gruen, Danièlle A Gunn-Moore, Kathleen Romanowski, Wendy Simpson, Christine Kirnos, Kathleen Keefe Ternes and 5 more

Abstract read
In one paragraph

Article in Frontiers in veterinary science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Elizabeth J ColleranChico Hospital for Cats, Chico, CA, United States.
Mikel M DelgadoFeline Minds Cat Behavior Consulting, Sacramento, CA, United States.
Yunyi RenDepartment of Public Health Sciences, School of Medicine, University of California, Davis, Davis, CA, United States.
Alexander J GermanInstitute of Life Course and Medical Sciences, Faculty of Health and Life Sciences, University of Liverpool, Neston, United Kingdom.
Margaret E GruenDepartment of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, United States.
Danièlle A Gunn-MooreThe Royal (Dick) School of Veterinary Studies and The Roslin Institute, The University of Edinburgh, Easter Bush Veterinary Campus, Edinburgh, United Kingdom.
Kathleen RomanowskiDepartment of Surgery, School of Medicine, University of California, Davis, Sacramento, CA, United States.
Wendy SimpsonMorrisville Cat Hospital, Morrisville, NC, United States.
Christine KirnosThe Cat Hospital of Media, Media, PA, United States.
Kathleen Keefe TernesThe Feline Hospital, Salem, MA, United States.
Judy KarniaScottsdale Cat Clinic, Scottsdale, AZ, United States.
Marybeth TemplesCivic Feline Clinic, Walnut Creek, CA, United States.
Sandra L TaylorDepartment of Public Health Sciences, School of Medicine, University of California, Davis, Davis, CA, United States.
Melissa BainDepartment of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, Davis, CA, United States.
C A Tony BuffingtonDepartment of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, Davis, CA, United States.

Funding

UC Davis Clinical and Translational Science CenterUL1TR001860 · NCATS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI KENYON, NICHOLAS J., LYLES, COURTNEY REES · 2016 to 2025
$47.3M
NCATS NIH HHS UL1 TR001860
6 · The paper itself

Abstract

Introduction: Human frailty has long been studied and dozens of "frailty scales" have been developed, but equivalent research is more limited in cats. This pilot study aimed to determine the feasibility of recruiting and retaining veterinary practices and owners, collecting study data, and analyzing results about frailty in older cats. Methods: Participating feline-exclusive practice veterinarians recruited cats aged 11-20 years, of either sex and of any breed. Owners completed a questionnaire about their cat and estimated its frailty. Study veterinarians also estimated the cat's frailty after obtaining a history, conducting a physical examination, and completing a separate questionnaire. The derived variables were used to investigate the following domains of frailty: (1) cognitive function; (2) behavior; (3) activity; (4) body weight; (5) body condition score; (6) muscle condition score; (7) any unexplained changes in weight, cognitive function, or eating behavior; and (8) the number of chronic diseases identified in the cat. Some cats were followed prospectively for 6 months, and mortality during this period was compared with frailty status, as determined by the veterinarian. Results: Half (6/12) of the veterinary practices invited to participate successfully recruited 273 owner-cat pairs, with baseline questionnaire results obtained from 189 owners (69%) and veterinarian questionnaires obtained for 210 cats (77%). Of 122 cats having both owner and veterinarian questionnaire results, 45 (37%) were classified as frail by the owner and 51 (42%) by the veterinarian, with 28 (23%) classified as frail on both questionnaires. Of the cats with follow-up data, 13 of the 64 cats (20%) reported by veterinarians to be frail died or were euthanased during the 6-month follow-up, compared with only 1 of 54 cats (2%) that were not reported to be frail (Fisher's exact test Discussion: Developing a brief feline frailty questionnaire (FFQ) was feasible, and the results of such assessments were associated with 6-month mortality. A larger definitive trial should be considered to explore further the (dis)agreement between owners and veterinarians and better understand which frailty signs owners might be missing.

Indexed as

comorbiditiesend of lifefelinepalliative carequality of lifesenior

Identifiers

PMID40078212
PMCPMC11897749

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.