Evidence map›Paper›PMID 40078195›Full record

ArticleObesity science & practice2025

Maternal and Cord Blood Lipids in Pregnant Women With Obesity and Their Impact on Neonatal and Placental Biometric Features.

Fausta Beneventi, Camilla Bellingeri, Irene De Maggio, Carolina Spada, Maria Paola Pandolfi, Alessina Bini Smaghi, Maura Cortese, Elisa Ligari, Claudia Alpini, Arsenio Spinillo

Abstract read
In one paragraph

Article in Obesity science & practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Fausta BeneventiDipartimento di Scienze Clinico-Chirurgiche Diagnostiche e Pediatriche Università di Pavia Pavia Italy.ORCID https://orcid.org/0000-0001-6482-9481
Camilla BellingeriUnità Operativa di Ostetricia e Ginecologia 1 Fondazione IRCCS Policlinico San Matteo Pavia Italy.
Irene De MaggioUnità Operativa di Ostetricia e Ginecologia 1 Fondazione IRCCS Policlinico San Matteo Pavia Italy.ORCID https://orcid.org/0000-0003-1293-0152
Carolina SpadaDipartimento di Scienze Clinico-Chirurgiche Diagnostiche e Pediatriche Università di Pavia Pavia Italy.
Maria Paola PandolfiDipartimento di Scienze Clinico-Chirurgiche Diagnostiche e Pediatriche Università di Pavia Pavia Italy.
Alessina Bini SmaghiDipartimento di Scienze Clinico-Chirurgiche Diagnostiche e Pediatriche Università di Pavia Pavia Italy.
Maura CorteseDipartimento di Scienze Clinico-Chirurgiche Diagnostiche e Pediatriche Università di Pavia Pavia Italy.
Elisa LigariDipartimento di Scienze Clinico-Chirurgiche Diagnostiche e Pediatriche Università di Pavia Pavia Italy.
Claudia AlpiniUnità Operativa di Laboratorio analisi chimico cliniche Fondazione IRCCS Policlinico San Matteo Pavia Italy.
Arsenio SpinilloDipartimento di Scienze Clinico-Chirurgiche Diagnostiche e Pediatriche Università di Pavia Pavia Italy.ORCID https://orcid.org/0000-0002-7755-1084

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Maternal obesity and excessive weight gain during pregnancy predispose to adverse fetal outcomes and health issues for the offspring. Although maternal lipids play an important role in excess fetal fat accretion, previous studies found heterogeneous results regarding which lipid fraction is most involved in excessive fetal growth in maternal obesity and the role of cord lipids. The aim of this study was to evaluate lipid concentrations in maternal and cord blood in pregnant women with and without obesity and to correlate lipid profile with neonatal and placental biometric parameters. Methods: This is a prospective case-control study comparing 58 pregnant women with and without obesity enrolled from January 2021 to January 2022 at IRCCS Policlinico San Matteo. Lipid profiles at trimesters and in cord blood were tested. Statistical analysis was conducted with a nonparametric rank-based approach for longitudinal data analysis. Results: In both overall and time point analyses, maternal lipid concentrations were higher in participants with obesity than in subjects without obesity. Women with obesity also had higher total cholesterol and triglyceride cord blood concentrations ( Conclusions: Compared with controls, obesity in pregnancy is associated with a significant increase in maternal and cord blood lipids, with a positive association between maternal and cord triglycerides and birthweight and placental weight. These findings suggest a further insight into maternal obesity pathophysiology leading to excessive fetal growth, dyslipidemia and insulin resistance in the offspring.

Indexed as

large for gestational ageobesityplacentapregnancytriglycerides

Identifiers

PMID40078195
PMCPMC11900895

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.