ArticleFrontiers in neurology2025
Pediatric MOG antibody-positive encephalitis with normal brain magnetic resonance imaging: a new spectrum associated with MOG antibodies?
Article in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Cerebellar Involvement in Immune-Mediated Pediatric Acute Ataxia: Clinical Spectrum, MRI Findings, and Predictors of MOG Antibody Positivity.Cerebellum (London, England) · 2026Article
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Authors and funding
7 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Objective: To facilitate the accurate identification of clinical characteristics associated with myelin oligodendrocyte glycoprotein (MOG) antibody positive encephalitis in children presenting with normal brain magnetic resonance imaging (MRI) findings. Method: Patients hospitalized at Children's Hospital of Chongqing Medical University from January 2016 to May 2024, who were positive for MOG antibodies and exhibited encephalitis symptoms with normal brain MRI findings, were retrospectively analyzed. Results: A total of 17 patients (7 males and 10 females; mean age: 9.2 ± 2.8 years) were enrolled in the study. The most prevalent clinical symptoms were fever (17/17), with a median duration of 15 days (IQR: 7.5-21 days), headaches (17/17), mild alterations in mental status (17/17), seizures (6/17), vomiting (6/17), decreased binocular vision (2/17), and hemiplegia (1/17). The majority of cases (15/17) exhibited leukocytosis in peripheral blood (mean: 20.63 ± 7.09 × 10 Conclusion: For patients presenting with encephalitis and normal brain MRI findings, early testing for anti-MOG antibody should be considered if they exhibit the following characteristics: (1) persistent fever; (2) elevated peripheral blood white blood cell (WBC) counts, with normal or slightly elevated PCT and CRP levels; (3) mild elevation of CSF WBC counts, normal or mildly elevated protein levels, and normal CSF glucose levels; and (4) ineffectiveness of antibiotic or antiviral therapy. Encephalitis with normal brain MRI may be regarded as a potential new spectrum associated with MOG antibodies, meriting additional exploration and consideration.
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