Evidence map›Paper›PMID 40078148›Full record

ArticlePhilosophical transactions. Series A, Mathematical, physical, and engineering sciences2025

Evaluating the predictive accuracy of ion-channel models using data from multiple experimental designs.

Joseph G Shuttleworth, Chon Lok Lei, Monique J Windley, Adam P Hill, Simon P Preston, Gary R Mirams

Abstract read
In one paragraph

Article in Philosophical transactions. Series A, Mathematical, physical, and engineering sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Evaluating the predictive accuracy of ion-channel models using data from multiple experimental designs.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2025
    Article
  2. Challenges and opportunities in uncertainty quantification for healthcare and biological systems.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2025
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Joseph G ShuttleworthCentre for Mathematical Medicine & Biology, School of Mathematical Sciences, University of Nottingham, Nottingham NG7 2RD, UK.ORCID 0000-0003-4884-6526
Chon Lok LeiInstitute of Translational Medicine, Faculty of Health Sciences, University of Macau, Macau, People's Republic of China.ORCID 0000-0003-0904-554X
Monique J WindleyComputational Cardiology Laboratory, Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales, Australia.ORCID 0000-0001-6829-3856
Adam P HillComputational Cardiology Laboratory, Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales, Australia.ORCID 0000-0002-6403-1282
Simon P PrestonCentre for Mathematical Medicine & Biology, School of Mathematical Sciences, University of Nottingham, Nottingham NG7 2RD, UK.ORCID 0000-0002-1910-4227
Gary R MiramsCentre for Mathematical Medicine & Biology, School of Mathematical Sciences, University of Nottingham, Nottingham NG7 2RD, UK.ORCID 0000-0002-4569-4312

Funding

Australian Research CouncilEPSRCFundo para o Desenvolvimento das Ciências e da TecnologiaUniversidade de MacauWellcome Trust
6 · The paper itself

Abstract

Mathematical models are increasingly being relied upon to provide quantitatively accurate predictions of cardiac electrophysiology. Many such models concern the behaviour of particular subcellular components (namely, ion channels) which, together, allow the propagation of electrical signals through heart-muscle tissue; that is, the firing of action potentials. In particular, I

Indexed as

Ion ChannelsAction PotentialsAnimalsHumansPatch-Clamp TechniquesResearch DesignIon ChannelselectrophysiologyhERGmathematical modeloptimizationvalidation

Identifiers

PMID40078148
PMCPMC11904619

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.