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ArticleActa dermato-venereologica2025

Patient Needs and Treatment Goals in Chronic Atopic Pruritus: Does Eczema Make a Difference?

Svenja Müller, Claudia Zeidler, Christian Mess, Stefan M Kahnert, Bernd Löwe, Angelika Weigel, Felix Witte, Volker Huck, Lynhda Nguyen, Matthias Augustin and 10 more

Abstract read
In one paragraph

Article in Acta dermato-venereologica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Svenja MüllerDepartment of Dermatology and Center for Chronic Pruritus (KCP), University Hospital Münster, Münster, Germany. svenja.mueller@ukmuenster.de.ORCID 0000-0002-2118-959X
Claudia ZeidlerDepartment of Dermatology and Center for Chronic Pruritus (KCP), University Hospital Münster, Münster, Germany.
Christian MessDepartment of Dermatology and Venereology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Stefan M KahnertDepartment of Psychosomatic Medicine and Psychotherapy, University Hospital Münster, Münster, Germany.
Bernd LöweDepartment of Psychosomatic Medicine and Psychotherapy, Centre for Internal Medicine, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.
Angelika WeigelDepartment of Psychosomatic Medicine and Psychotherapy, Centre for Internal Medicine, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.
Felix WitteDepartment of Dermatology and Center for Chronic Pruritus (KCP), University Hospital Münster, Münster, Germany.
Volker HuckDepartment of Dermatology and Venereology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Lynhda NguyenDepartment of Dermatology and Venereology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Matthias AugustinInstitute for Health Services Research in Dermatology and Nursing (IVDP), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.
Gina FrankDepartment of Psychosomatic Medicine and Psychotherapy, University Hospital Münster, Münster, Germany.
Konstantin AgelopoulosDepartment of Dermatology and Center for Chronic Pruritus (KCP), University Hospital Münster, Münster, Germany.
Henning WiegmannDepartment of Dermatology and Center for Chronic Pruritus (KCP), University Hospital Münster, Münster, Germany.
Ansgar KöchelDepartment of Psychosomatic Medicine and Psychotherapy, University Hospital Münster, Münster, Germany.
Rupert ConradDepartment of Psychosomatic Medicine and Psychotherapy, University Hospital Münster, Münster, Germany.
Gudrun SchneiderDepartment of Psychosomatic Medicine and Psychotherapy, University Hospital Münster, Münster, Germany.
Stefan W SchneiderDepartment of Dermatology and Venereology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Sonja StänderDepartment of Dermatology and Center for Chronic Pruritus (KCP), University Hospital Münster, Münster, Germany.
Inga Hansen-AbeckDepartment of Dermatology and Venereology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Finn AbeckDepartment of Dermatology and Venereology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic pruritus (≥ 6 weeks) is a frequent symptom in atopic diseases, with phenotypes ranging from non-lesional skin to inflammatory diseases like atopic dermatitis. Data on patients' needs and treatment goals depending on the skin phenotype and disease burden are limited. This study aimed to analyse the impact of distinct phenotypes of chronic atopic pruritus on disease burden and treatment goals. Another objective was to investigate whether the disease burden influences the treatment goals. Patient-reported outcomes of 1,086 adult patients (n = 529 with atopic dermatitis, n = 557 with chronic pruritus on non-lesional skin with atopic skin diathesis) were analysed age- and gender-matched (mean age 49.7 ± 19.0 years; n = 605 female [55.7%]), comparing pruritus intensity (Numeric Rating Scale), quality of life (Dermatology Life Quality Index, ItchyQol), anxiety and depression (Hospital Anxiety and Depression Scale), and patient needs (Patient Needs Questionnaire of the Patient Benefit Index-Pruritus). Although the disease burden was significantly higher in patients with atopic dermatitis (prolonged disease duration, increased quality of life impairment, higher pruritus intensity), the treat-ment goals of both phenotypes matched in 92.6%. The most important needs were to no longer experience itching, find a clear diagnosis and therapy, and have confidence in the therapy.

Indexed as

Dermatitis, AtopicEczemaHealth Services Needs and DemandNeeds AssessmentPruritusAdultAgedAnxietyChronic DiseaseCost of IllnessDepressionFemaleHumansMaleMiddle AgedPatient Reported Outcome Measures

Identifiers

PMID40077979
PMCPMC11926422

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.