Evidence map›Paper›PMID 40077792›Full record

ArticleNutrients2025

Host Transcriptome and Microbial Variation in Relation to Visceral Hyperalgesia.

Christopher J Costa, Stephanie Prescott, Nicolaas H Fourie, Sarah K Abey, LeeAnne B Sherwin, Bridgett Rahim-Williams, Paule V Joseph, Hugo Posada-Quintero, Rebecca K Hoffman, Wendy A Henderson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Christopher J CostaDepartment of Medicine, UConn Health, 263 Farmington Ave, Farmington, CT 06030, USA.ORCID 0000-0002-2648-0757
Stephanie PrescottInova Health Services, L.J. Murphy Children's Hospital, 3300 Gallows Rd, Falls Church, VA 22042, USA.
Nicolaas H FourieNational Institute of Nursing Research, National Institutes of Health, 31 Center Drive, Bethesda, MD 20892, USA.
Sarah K AbeyLaboratory of Neuroimaging, National Institute of Alcohol Abuse and Alcoholism, 10 Center Drive, Bethesda, MD 20814, USA.
LeeAnne B SherwinSinclair School of Nursing, University of Missouri System, 915 Hitt Street, Columbia, MO 65203, USA.
Bridgett Rahim-WilliamsOffice of Research and Sponsored Programs, University of North Florida, 1 UNF Drive, Jacksonville, FL 32224, USA.ORCID 0000-0002-9208-3004
Paule V JosephNational Institute on Alcohol Abuse and Alcoholism, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, 10 Center Drive, Bethesda, MD 20814, USA.ORCID 0000-0002-1198-9622
Hugo Posada-QuinteroDepartment of Biomedical Engineering, University of Connecticut, 260 Glenbrook Road, Storrs, CT 06269, USA.ORCID 0000-0003-4514-4772
Rebecca K HoffmanLaboratory of Innovative and Translational Nursing Research, School of Nursing, University of PA, 418 Curie Blvd, Philadelphia, PA 19104, USA.
Wendy A HendersonDepartment of Biobehavioral Health Sciences, School of Nursing, University of PA, 418 Curie Blvd, Philadelphia, PA 19104, USA.ORCID 0000-0003-3924-7118

Funding

Symptom Distress Mechanisms in Digestive DisordersZIANR000018 · NINR · NATIONAL INSTITUTE OF NURSING RESEARCH · PI HENDERSON, WENDY · 2009 to 2019
$5.2M
Exergame Physical Activity, Pain, and Functional Mobility Among Women with Knee OsteoarthritisK22MD006143 · NIMHD · BETHUNE-COOKMAN COLLEGE · PI RAHIM-WILLIAMS, BRIDGETT · 2015 to 2017
$710k
CCR NIH HHS HHSN261200800001CIntramural NIH HHS ZIA NR000018NCI NIH HHS HHSN261200800001ENIH HHS 1ZIANR000018-01-09; K22MD006143-01NIMHD NIH HHS K22 MD006143
6 · The paper itself

Abstract

backgroundChronic visceral hypersensitivity is associated with an overstressed pain response to noxious stimuli (hyperalgesia). Microbiota are active modulators of host biology and are implicated in the etiology of visceral hypersensitivity.

objectiveswe studied the association between the circulating mRNA transcriptome, the intensity of induced visceral pain (IVP), and variation in the oral microbiome among participants with and without baseline visceral hypersensitivity.

methodsTranscriptomic profiles and microbial abundance were correlated with IVP intensity. Host mRNA and microbes associated with IVP were explored, linking variation in the microbiome to host RNA biology.

results259 OTUs were found to be associated with IVP through correlation to differential expression of 471 genes in molecular pathways related to inflammation and neural mechanisms, including Rho and PI3K/AKT pathways. The bacterial families Lachnospiraceae, Prevotellaceae, and Veillonellaceae showed the highest degree of association. Oral microbial profiles with reduced diversity were characteristic of participants with visceral hypersensitivity.

conclusionsOur results suggest that the oral microbiome may be involved in systemic immune and inflammatory effects and play a role in nervous system and stem cell pathways. The interactions between visceral hypersensitivity, differentially expressed molecular pathways, and microbiota described here provide a framework for further work exploring the relationship between host and microbiome.

Indexed as

Gastrointestinal MicrobiomeHyperalgesiaMicrobiotaTranscriptomeVisceral PainAdultFemaleHumansMaleMiddle AgedMouthRNA, MessengerRNA, Messengerabdominal painabdominal pain [D015746]gene expressionhuman microbiome [D064307]microbiomeoralvisceral hyperalgesiavisceral pain [D064307]

Identifiers

PMID40077792
PMCPMC11902232

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.