ReviewNutrients2025
The "Jekyll Side" of the S100B Protein: Its Trophic Action in the Diet.
Review in Nutrients, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Biomarkers associated with blood-brain interface regulation and relationships to exercise and epilepsy: a brief review.Frontiers in rehabilitation sciences · 2026Review
- The Estimated Intake of S100B Relates to Microbiota Biodiversity in Different Diets.Biomolecules · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The calcium-binding S100B protein is concentrated in glial cells (including enteroglial cells) in the nervous system. Its conformation and amino acid composition are significantly conserved in different species; this characteristic suggests conserved biological role(s) for the protein. The biological activity is concentration-dependent: low physiological concentrations exert a neurotrophic effect, while high concentrations exert a proinflammatory/toxic role. The proinflammatory/toxic role of S100B currently attracts the scientific community's primary attention, while the protein's physiological action remains unraveled-yet remarkably interesting. This is now a topical issue due to the recently consolidated notion that S100B is a natural trophic nutrient available in breast milk and/or other aliments, possibly interacting with other body districts through its impact on microbiota. These recent data may offer novel clues to understanding the role of this challenging protein.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.