Evidence map›Paper›PMID 40077663›Full record

ReviewNutrients2025

Dietary Guidance, Sensory, Health and Safety Considerations When Choosing Low and No-Calorie Sweeteners.

John L Sievenpiper, Sidd Purkayastha, V Lee Grotz, Margaux Mora, Jing Zhou, Katherine Hennings, Cynthia M Goody, Kristen Germana

Abstract readReview
In one paragraph

Review in Nutrients, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Baru Almond Beverage (Foods (Basel, Switzerland) · 2026
    Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

John L SievenpiperDepartment of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A1, Canada.
Sidd PurkayasthaSP Advisors Inc., Chicago, IL 60605, USA.
V Lee GrotzToxInsight, LLC, Fort Washington, PA 19034, USA.
Margaux MoraIngredion Inc., Bridgewater, NJ 08807, USA.ORCID 0000-0003-2650-9158
Jing ZhouIngredion Inc., Bridgewater, NJ 08807, USA.ORCID 0000-0002-8936-8826
Katherine HenningsPureCircle by Ingredion Inc., Westchester, IL 60154, USA.
Cynthia M GoodyGrow A Food Career, LLC, Elmhurst, IL 60126, USA.
Kristen GermanaIngredion Inc., Bridgewater, NJ 08807, USA.

Funding

Ingredion Incorporated Not applicable
6 · The paper itself

Abstract

The growing global focus on the adverse health conditions associated with excessive sugar consumption has prompted health and policy organizations as well as the public to take a more mindful approach to health and wellness. In response, food and beverage companies have proactively innovated and reformulated their product portfolios to incorporate low and no-calorie sweeteners (LNCSs) as viable alternatives to sugar. LNCSs offer an effective and safe approach to delivering sweetness to foods and beverages and reducing calories and sugar intake while contributing to the enjoyment of eating. The objective of this paper is to enhance the understanding of LNCSs segmentation and definitions, dietary consumption and reduction guidance, front-of-package labeling, taste and sensory perception and physiology, metabolic efficacy and impact, as well as the overall safety of LNCSs and sugar.

Indexed as

Energy IntakeNon-Nutritive SweetenersNutrition PolicySweetening AgentsFood LabelingHumansTasteNon-Nutritive SweetenersSweetening Agentsdietary guidancehealthlow and no-calorie sweetenerssafetysensory

Identifiers

PMID40077663
PMCPMC11902030

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.