Evidence map›Paper›PMID 40077595›Full record

ArticleFoods (Basel, Switzerland)2025

Synergistic Neuroprotection Through Epigenetic Modulation by Combined Curcumin-Enriched Turmeric Extract and L-Ascorbic Acid in Oxidative Stress-Induced SH-SY5Y Cell Damage.

Jurairat Khongrum, Nootchanat Mairuae, Tongjit Thanchomnang, Man Zhang, Gang Bai, Nut Palachai

Abstract read
In one paragraph

Article in Foods (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Experimental evaluation ofExperimental and therapeutic medicine · 2026
    Article
  2. Article
  3. Synergistic Effects of Anthocyanin-EnrichedFoods (Basel, Switzerland) · 2025
    Article
  4. Synergistic Antioxidant Effects of C3G-EnrichedInternational journal of molecular sciences · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jurairat KhongrumMultidisciplinary Research Institute, Chiang Mai University, Chiang Mai 50200, Thailand.ORCID 0000-0003-0347-2516
Nootchanat MairuaeBiomedical Research Unit, Faculty of Medicine, Mahasarakham University, Mahasarakham 44000, Thailand.ORCID 0000-0002-6407-2463
Tongjit ThanchomnangBiomedical Research Unit, Faculty of Medicine, Mahasarakham University, Mahasarakham 44000, Thailand.
Man ZhangState Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300353, China.
Gang BaiState Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300353, China.ORCID 0000-0001-9161-2173
Nut PalachaiBiomedical Research Unit, Faculty of Medicine, Mahasarakham University, Mahasarakham 44000, Thailand.ORCID 0000-0002-9672-9941

Funding

Mahasarakham University
6 · The paper itself

Abstract

Epigenetic modulation plays a crucial role in neuroprotection by regulating cellular responses to stress, inflammation, and oxidative damage, particularly in neurodegenerative diseases. Recognizing the therapeutic potential of epigenetic regulators, this study investigated the synergistic neuroprotective effects of curcumin-enriched turmeric extract combined with L-ascorbic acid, focusing on its modulation of epigenetic pathways in oxidative stress-induced neuronal damage. SH-SY5Y neuronal cells were treated with the combination at 20 and 40 µg/mL, and subsequently exposed to 200 µM hydrogen peroxide (H

Indexed as

curcuminepigeneticsL-ascorbic acidneurodegenerative diseasesturmeric

Identifiers

PMID40077595
PMCPMC11898916

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.