Preparation, Characterization, and Safety Evaluation of a Submicron Emulsion Processed Using High-Pressure Homogenization to Protect Bitter Melon Seed Oil.

Huiling Wang, Heng Guo, Xiaoyan Shuai, Yan Ma, Rui Zhang, Muci Wu, Jingren He, Jiayan Ling

Abstract read

In one paragraph

Article in Foods (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

8 authors.

Huiling WangNational R&D Center for Se-Rich Agricultural Products Processing, School of Modern Industry for Selenium Science and Engineering, Wuhan Polytechnic University, Wuhan 430023, China.ORCID 0000-0001-9218-4625

Heng GuoDepartment of Pharmacy, Wuhan No. 1 Hospital (Traditional Chinese and Western Medicine Hospital of Wuhan), Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430023, China.

Xiaoyan ShuaiNational R&D Center for Se-Rich Agricultural Products Processing, School of Modern Industry for Selenium Science and Engineering, Wuhan Polytechnic University, Wuhan 430023, China.

Yan MaNational R&D Center for Se-Rich Agricultural Products Processing, School of Modern Industry for Selenium Science and Engineering, Wuhan Polytechnic University, Wuhan 430023, China.

Rui ZhangNational R&D Center for Se-Rich Agricultural Products Processing, School of Modern Industry for Selenium Science and Engineering, Wuhan Polytechnic University, Wuhan 430023, China.

Muci WuNational R&D Center for Se-Rich Agricultural Products Processing, School of Modern Industry for Selenium Science and Engineering, Wuhan Polytechnic University, Wuhan 430023, China.

Jingren HeNational R&D Center for Se-Rich Agricultural Products Processing, School of Modern Industry for Selenium Science and Engineering, Wuhan Polytechnic University, Wuhan 430023, China.

Jiayan LingDepartment of Traditional Chinese Medicine, Wuhan No. 1 Hospital (Traditional Chinese and Western Medicine Hospital of Wuhan), Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430023, China.

Funding

Hubei Province Fruit and Vegetable Intensive Processing; the Plant Polypeptide Nutritional Functional Food Development Enterprise-University Joint Innovation Center No. whpu-2020-kj-304Key Technique of Green Extraction and Separation of Protein Polypeptides from Cucurbitaceae Fruit and Vegetable No. whpu-2021-kj-260Study of Preparation and Evaluation Technique of Bitter Melon Seed CLNA Oil Multilayer Emulsion No. whpu-2021-kj-259

6 · The paper itself

Abstract

Bitter melon seed oil (BMSO), as a by-product of bitter gourd fruit processing, is rich in active ingredients and has unique medicinal potential. However, its solubility and dispersibility in water are poor when used directly. Therefore, this study aims to develop an eco-friendly submicron emulsion containing BMSO for intravenous injection and evaluate its safety. The BMSO submicron emulsion (BMSOSE) was prepared by high-pressure homogenization. The size, polydispersity index (PDI), ζ-potential, Turbiscan stability index (TSI), apparent viscosity, and morphology were characterized; in addition, an in vitro hemolysis test and acute toxicity test in mice were investigated in detail to evaluate the emulsion. The results demonstrated that the formulation and technological parameters of the BMSOSE were as follows: BMSO, 8% (

Indexed as

bitter melon seed oilformulation and preparationphysicochemical propertiessafety evaluationsubmicron emulsion

Identifiers

PMID40077553

DOI10.3390/foods14050850

PMCPMC11899332

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