ArticleFoods (Basel, Switzerland)2025
Mixture Design and Doehlert Matrix for Optimization of Energized Dispersive Guided Extraction (EDGE) of Theobromine and Caffeine from Cocoa Bean Shells.
Article in Foods (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Extraction of high-value compounds from Theobroma grandiflorum (cupuassu) seed shells using pressurized liquid extraction with NADES: a green chemistry approach.Analytical and bioanalytical chemistry · 2026Article
- Chromatographic Profiling of Artisanal Chocolates: Volatile Composition and Methylxanthines as Markers of Cocoa Content.Journal of food science · 2026Article
- Insecticidal potential of Areca catechu nut extract against multiple life stages of Aedes aegypti and Aedes albopictus.PloS one · 2026Article
- Article
- Enhanced Energized Dispersive-Guided Extraction Using Doehlert Matrix Optimization and Antioxidant Evaluation of Phenolic Compounds From Herbal Leaves by Using High-Performance Liquid Chromatography.Journal of separation science · 2025Article
- From Waste to Biocatalyst: Cocoa Bean Shells as Immobilization Support and Substrate Source in Lipase-Catalyzed Hydrolysis.Molecules (Basel, Switzerland) · 2025Article
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Authors and funding
11 authors.
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Abstract
This work describes the development of a method for the extraction of methylxanthines from cocoa bean shell (CBS) by employing the novel Energized Dispersive Guided Extraction (EDGE) system. The mixtures were composed of ethanol-methanol-water and the ratio was optimized using a simplex-centroid design. Doehlert design (DD) was used to optimize the variables of temperature and time while using methylxanthine content obtained by HPLC-DAD as an analytical response. The optimized mixture consisted of water-ethanol in a 3:2 ratio. The optimum operating conditions for extraction were achieved at a temperature of 148.5 °C and 382 s. Under optimal conditions, 20.14 mg g
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