Evidence map›Paper›PMID 40077225›Full record

ArticleMaterials (Basel, Switzerland)2025

The Role of Crosslinking Agents in the Development of Collagen-Hydroxyapatite Composite Materials for Bone Tissue Engineering.

Alina Florentina Vladu, Madalina Georgiana Albu Kaya, Roxana Doina Truşcă, Ludmila Motelica, Vasile-Adrian Surdu, Ovidiu Cristian Oprea, Rodica Roxana Constantinescu, Bogdan Cazan, Denisa Ficai, Ecaterina Andronescu and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Antibiotics (Basel, Switzerland) · 2025
    Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Alina Florentina VladuThe National Research and Development Institute for Textiles and Leather, Lucretiu Patrascanu, 030508 Bucharest, Romania.ORCID 0000-0001-7599-719X
Madalina Georgiana Albu KayaDivision of Leather and Footwear Research Institute, The National Research and Development Institute for Textiles and Leather, 93 Ion Minulescu Str., 031215 Bucharest, Romania.ORCID 0000-0001-9960-2244
Roxana Doina TruşcăScience and Engineering of Oxide Materials and Nanomaterials, Faculty of Chemical Engineering and Biotechnologies, National University of Science and Technology POLITEHNICA Bucharest, Gh. Polizu 1-7, 011061 Bucharest, Romania.
Ludmila MotelicaScience and Engineering of Oxide Materials and Nanomaterials, Faculty of Chemical Engineering and Biotechnologies, National University of Science and Technology POLITEHNICA Bucharest, Gh. Polizu 1-7, 011061 Bucharest, Romania.ORCID 0000-0002-3371-4136
Vasile-Adrian SurduScience and Engineering of Oxide Materials and Nanomaterials, Faculty of Chemical Engineering and Biotechnologies, National University of Science and Technology POLITEHNICA Bucharest, Gh. Polizu 1-7, 011061 Bucharest, Romania.ORCID 0000-0002-4207-5380
Ovidiu Cristian OpreaScience and Engineering of Oxide Materials and Nanomaterials, Faculty of Chemical Engineering and Biotechnologies, National University of Science and Technology POLITEHNICA Bucharest, Gh. Polizu 1-7, 011061 Bucharest, Romania.ORCID 0000-0002-8145-1094
Rodica Roxana ConstantinescuDivision of Leather and Footwear Research Institute, The National Research and Development Institute for Textiles and Leather, 93 Ion Minulescu Str., 031215 Bucharest, Romania.
Bogdan CazanThe National Research and Development Institute for Textiles and Leather, Lucretiu Patrascanu, 030508 Bucharest, Romania.ORCID 0009-0004-4625-1208
Denisa FicaiNational Center for Micro and Nanomaterials, National University of Science and Technology POLITEHNICA Bucharest, Splaiul Independentei 313, 060042 Bucharest, Romania.ORCID 0000-0003-1243-6904
Ecaterina AndronescuScience and Engineering of Oxide Materials and Nanomaterials, Faculty of Chemical Engineering and Biotechnologies, National University of Science and Technology POLITEHNICA Bucharest, Gh. Polizu 1-7, 011061 Bucharest, Romania.ORCID 0000-0002-2226-5849
Anton FicaiScience and Engineering of Oxide Materials and Nanomaterials, Faculty of Chemical Engineering and Biotechnologies, National University of Science and Technology POLITEHNICA Bucharest, Gh. Polizu 1-7, 011061 Bucharest, Romania.ORCID 0000-0002-1777-0525

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The lack of bone grafts represents a major issue in the orthopedic field, reconstructive surgery, and dentistry. There are several bone conditions that often demand the use of grafts, such as fractures, infections, and bone cancer. The number of bone cancer cases increased in the past few decades and along with it, the need for bone grafting materials. To avoid the use of autografts and allografts there has been an increased interest towards synthetic grafts. This research aims to develop some collagen/hydroxyapatite (Coll/HAp) scaffolds cross-linked with three different agents that could be used in bone tissue engineering (BTE). These scaffolds were obtained with a freeze-drying method after the in situ formation of hydroxyapatite inside the collagen matrix. They were structurally and morphologically characterized and evaluated in terms of antimicrobial activity on

Indexed as

bone tissue engineeringcomposite materialsfreeze-dryingin situ hydroxyapatite

Identifiers

PMID40077225
PMCPMC11901301

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.