Evidence map›Paper›PMID 40076957›Full record

ArticleInternational journal of molecular sciences2025

Characterization of Salivary Microbiota in Japanese Patients with Oral Cancer.

Kenichi Kumagai, Shigeo Ishikawa, Mitsuyoshi Iino, Kaoru Edamatsu, Naoki Okuyama, Kazuyuki Yusa, Yudai Shimizu, Reo Aoki, Chieko Masuda, Yoshihiro Ohashi and 3 more

Abstract read
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In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Kenichi KumagaiDepartment of Oral-Maxillofacial Surgery and Orthodontics, The University of Tokyo Hospital, Tokyo 113-8655, Japan.
Shigeo IshikawaDepartment of Dentistry, Oral and Maxillofacial Plastic and Reconstructive Surgery, Faculty of Medicine, Yamagata University, 2-2-2 Iida-Nishi, Yamagata 990-9585, Japan.
Mitsuyoshi IinoDepartment of Oral and Maxillofacial Surgery, Shinjo Tokushukai Hospital, 1-1, 4623, Shinjo, Yamagata 996-0041, Japan.
Kaoru EdamatsuDepartment of Dentistry, Oral and Maxillofacial Plastic and Reconstructive Surgery, Faculty of Medicine, Yamagata University, 2-2-2 Iida-Nishi, Yamagata 990-9585, Japan.
Naoki OkuyamaDepartment of Dentistry, Oral and Maxillofacial Plastic and Reconstructive Surgery, Faculty of Medicine, Yamagata University, 2-2-2 Iida-Nishi, Yamagata 990-9585, Japan.
Kazuyuki YusaDepartment of Dentistry, Oral and Maxillofacial Plastic and Reconstructive Surgery, Faculty of Medicine, Yamagata University, 2-2-2 Iida-Nishi, Yamagata 990-9585, Japan.
Yudai ShimizuDepartment of Oral and Maxillofacial Surgery, Kanto Rosai Hospital, 1-1, Kizukisumiyoshi, Nakahara-ku, Kawasaki 211-8510, Japan.ORCID 0009-0001-7088-9816
Reo AokiDepartment of Oral and Maxillofacial Surgery, Kanto Rosai Hospital, 1-1, Kizukisumiyoshi, Nakahara-ku, Kawasaki 211-8510, Japan.
Chieko MasudaDepartment of Oral and Maxillofacial Surgery, Kanto Rosai Hospital, 1-1, Kizukisumiyoshi, Nakahara-ku, Kawasaki 211-8510, Japan.
Yoshihiro OhashiDepartment of Oral and Maxillofacial Surgery, Kanto Rosai Hospital, 1-1, Kizukisumiyoshi, Nakahara-ku, Kawasaki 211-8510, Japan.
Akihisa HorieDepartment of Oral and Maxillofacial Surgery, Kanto Rosai Hospital, 1-1, Kizukisumiyoshi, Nakahara-ku, Kawasaki 211-8510, Japan.
Kazuto HoshiDepartment of Oral-Maxillofacial Surgery and Orthodontics, The University of Tokyo Hospital, Tokyo 113-8655, Japan.
Yoshiki HamadaDepartment of Oral and Maxillofacial Surgery, School of Dental Medicine, Tsurumi University, 2-1-3 Tsurumi, Tsurumi-ku, Yokohama 230-8501, Japan.

Funding

JSPS KAKENHI Grant-in-Aid for Scientific Research (C) JP 22K10113
6 · The paper itself

Abstract

This study aimed to characterize salivary microbiota in patients with oral cancer using 16S rRNA amplicon sequencing. DNA was extracted from saliva samples of 23 patients with oral cancer and 95 age-matched controls. A metagenomic analysis was performed using 16S rRNA amplicon sequencing. Patients with oral cancer exhibited lower α-diversity, as indicated by the Chao-1 index, compared to the control group, and significant differences in β-diversity were observed between the two groups. At the genus level, 25 bacterial species such as

Indexed as

BacteriaMicrobiotaMouth NeoplasmsSalivaAdultAgedCase-Control StudiesEast Asian PeopleFemaleHumansJapanMaleMetagenomicsMiddle AgedRNA, Ribosomal, 16SRNA, Ribosomal, 16S16S rRNAhigh-throughput sequencingoral canceroral squamous cell carcinomasalivary microbiome

Identifiers

PMID40076957
PMCPMC11900280

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.