Evidence map›Paper›PMID 40076925›Full record

ArticleInternational journal of molecular sciences2025

Antiproliferative Role of Natural and Semi-Synthetic Tocopherols on Colorectal Cancer Cells Overexpressing the Estrogen Receptor β.

Irene Falsetti, Gaia Palmini, Roberto Zonefrati, Kristian Vasa, Simone Donati, Cinzia Aurilia, Allegra Baroncelli, Caterina Viglianisi, Francesco Ranaldi, Teresa Iantomasi and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Significance of Vitamins A and E in Cancer Progression and Prevention.International journal of molecular sciences · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Irene FalsettiDepartment of Experimental and Clinical Biomedical Sciences "Mario Serio", University of Florence, Viale Pieraccini 6, 50139 Firenze, Italy.
Gaia PalminiItalian Foundation for Research on Bone Disease (F.I.R.M.O.), Via San Gallo 123, 50129 Firenze, Italy.ORCID 0000-0002-8376-7404
Roberto ZonefratiItalian Foundation for Research on Bone Disease (F.I.R.M.O.), Via San Gallo 123, 50129 Firenze, Italy.
Kristian VasaDepartment of Chemistry "Ugo Schiff", University of Florence, Via Della Lastruccia, 3-13, 50019 Sesto Fiorentino, Italy.ORCID 0000-0001-7014-5115
Simone DonatiDepartment of Experimental and Clinical Biomedical Sciences "Mario Serio", University of Florence, Viale Pieraccini 6, 50139 Firenze, Italy.
Cinzia AuriliaDepartment of Experimental and Clinical Biomedical Sciences "Mario Serio", University of Florence, Viale Pieraccini 6, 50139 Firenze, Italy.
Allegra BaroncelliDepartment of Chemistry "Ugo Schiff", University of Florence, Via Della Lastruccia, 3-13, 50019 Sesto Fiorentino, Italy.
Caterina ViglianisiDepartment of Chemistry "Ugo Schiff", University of Florence, Via Della Lastruccia, 3-13, 50019 Sesto Fiorentino, Italy.ORCID 0000-0002-2451-5856
Francesco RanaldiDepartment of Experimental and Clinical Biomedical Sciences "Mario Serio", University of Florence, Viale Pieraccini 6, 50139 Firenze, Italy.ORCID 0000-0003-1816-8859
Teresa IantomasiDepartment of Experimental and Clinical Biomedical Sciences "Mario Serio", University of Florence, Viale Pieraccini 6, 50139 Firenze, Italy.ORCID 0000-0001-7461-330X
Piero ProcacciDepartment of Chemistry "Ugo Schiff", University of Florence, Via Della Lastruccia, 3-13, 50019 Sesto Fiorentino, Italy.
Stefano MenichettiDepartment of Chemistry "Ugo Schiff", University of Florence, Via Della Lastruccia, 3-13, 50019 Sesto Fiorentino, Italy.ORCID 0000-0001-6745-7484
Maria Luisa BrandiItalian Foundation for Research on Bone Disease (F.I.R.M.O.), Via San Gallo 123, 50129 Firenze, Italy.ORCID 0000-0002-8741-0592

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Estrogen receptor β (ERβ) is the most highly expressed subtype in the colon epithelium and mediates the protective effect of estrogen against the development of colon cancer. Indeed, the expression of this receptor is inversely related to colorectal cancer progression. Structurally estrogen-like compounds, including vitamin E components, affect cell growth by binding to ERs. In the present study, cell proliferation was measured by cell counting in a Bürker hemocytometer, and ERβ expression was measured by Real-Time qPCR and immunoenzymatic methods. The results obtained show that natural δ-tocopherol (

Indexed as

Cell ProliferationColorectal NeoplasmsEstrogen Receptor betaTocopherolsCell Line, TumorEstradiolGene Expression Regulation, NeoplasticHumansEstradiolEstrogen Receptor betaTocopherolscell proliferationcolorectal cancerestrogen receptor βreactive oxygen speciesδ-tocopherolδ-tocopherol sulfide/disulfide

Identifiers

PMID40076925
PMCPMC11900421

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.