Alternative Splicing Analysis Reveals Adrenergic Signaling as a Novel Target for Protein Arginine Methyltransferase 5 (PRMT5) in the Heart.

Shouye Jiao, Yimeng Zhang, Xiao Yang, Jian Wang, Zhenhua Li

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Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

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3 · Its place in the literature

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1 citing paper in PubMed.

Shaping Spliceosome Dynamics Through Protein Arginine Methylation.Wiley interdisciplinary reviews. RNA
Review

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5 · Who and what money

Authors and funding

5 authors.

Shouye JiaoDepartment of Cell Biology, School of Basic Medicine, Qingdao University, Qingdao 266071, China.

Yimeng ZhangDepartment of Cell Biology, School of Basic Medicine, Qingdao University, Qingdao 266071, China.

Xiao YangState Key Laboratory of Medical Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences, Beijing Institute of Lifeomics, Beijing 102206, China.

Jian WangState Key Laboratory of Medical Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences, Beijing Institute of Lifeomics, Beijing 102206, China.

Zhenhua LiState Key Laboratory of Medical Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences, Beijing Institute of Lifeomics, Beijing 102206, China.ORCID 0000-0001-6327-9561

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adrenergic signaling is critical for maintaining cardiac function and works by regulating heart rate, contractility, and stress responses. Protein arginine methyltransferase 5 (PRMT5), a key enzyme involved in gene expression, signal transduction, and RNA processing, has been revealed to be an important factor in heart disease. However, its specific effects on adrenergic signaling have not been fully elucidated. In this study, we examined the role of PRMT5 in the heart by analyzing alternative splicing events in cardiac tissues from

Indexed as

Alternative SplicingMyocardiumProtein-Arginine N-MethyltransferasesSignal TransductionAnimalsMaleMiceMice, Inbred C57BLMice, KnockoutPrmt5 protein, mouseProtein-Arginine N-Methyltransferasesadrenergic signalingalternative splicingheart diseasePRMT5

Identifiers

PMID40076920

DOI10.3390/ijms26052301

PMCPMC11899901

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.