Comparative Hypothalamic Proteomic Analysis Between Diet-Induced Obesity and Diet-Resistant Rats.

Pengjiao Xi, Shuhui Ma, Derun Tian, Yanna Shen

Abstract readComparative Study

In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 authors.

Pengjiao XiCollege of Medical Technology, Tianjin Medical University, Tianjin 300203, China.

Shuhui MaCollege of Medical Technology, Tianjin Medical University, Tianjin 300203, China.

Derun TianDepartment of Human Anatomy and Histology, Tianjin Medical University, Tianjin 300070, China.

Yanna ShenCollege of Medical Technology, Tianjin Medical University, Tianjin 300203, China.ORCID 0000-0001-5643-1916

Funding

the Scientific Research Project of Tianjin Education Commission 2020KJ205

6 · The paper itself

Abstract

Obesity arises from a complex interplay of genetic and environmental factors. Even among individuals with the same genetic predisposition, diet-induced obesity (DIO) exhibits varying degrees of susceptibility, which are categorized as DIO and diet-induced obesity resistance (DR). The hypothalamus plays a pivotal role in regulating energy homeostasis. This study performed a comparative hypothalamic proteomic analysis in DIO and DR rats to identify differentially expressed proteins (DEPs) associated with alterations in body weight. Male Sprague Dawley rats were fed either a standard chow diet or a high-fat diet for 12 weeks. DIO rats exhibited the most rapid weight gain compared to both the control and DR rats. Despite consuming similar caloric intake, DR rats exhibited less weight gain relative to DIO rats. Proteomic analysis revealed 31 DEPs in the hypothalamus of DR rats compared to DIO rats (with a false discovery rate (FDR) < 1%). Notably, 14 proteins were upregulated and 17 proteins were downregulated in DR rats. Gene ontology analysis revealed an enrichment of ion-binding proteins, such as those binding to Fe

Indexed as

Diet, High-FatHypothalamusObesityProteomeProteomicsAnimalsMaleRatsRats, Sprague-DawleyProteomediet-induced obesity resistancehypothalamusobesityproteomic

Identifiers

PMID40076916

DOI10.3390/ijms26052296

PMCPMC11899849

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