Evidence map›Paper›PMID 40076871›Full record

ReviewInternational journal of molecular sciences2025

Diterpenes: Nature's Hidden Gems of Immunomodulation.

Josiane Elizabeth Almeida, André Correa de Oliveira, Carlos Eduardo de Castro Alves, Selino Monteiro Costa Filho, Elaine Cristina Pacheco de Oliveira, Juliana Pavan Zuliani, Gemilson Soares Pontes

Erratum issuedAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Phytochemical properties ofFrontiers in pharmacology · 2026
    Article
  4. Article
  5. In vitro effect of Mikania cordata leaf extracts on wound healing.BMC complementary medicine and therapies · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Josiane Elizabeth AlmeidaGraduate Program in Basic and Applied Immunology, Federal University of Amazonas (UFAM), Manaus 69080-900, AM, Brazil.
André Correa de OliveiraAnalytical Multidisciplinary Support Center, Federal University of Amazonas (UFAM), Manaus 69080-900, AM, Brazil.ORCID 0000-0001-9258-3108
Carlos Eduardo de Castro AlvesLaboratory of Virology and Immunology, Society, Environment and Health Coordination, National Institute of Amazonian Research (INPA), Manaus 69080-001, AM, Brazil.
Selino Monteiro Costa FilhoBiotechnology and Medicinal Plants Laboratory, Federal University of Western Pará (UFOPA), Santarém 68040-255, PA, Brazil.ORCID 0009-0009-9867-3484
Elaine Cristina Pacheco de OliveiraBiotechnology and Medicinal Plants Laboratory, Federal University of Western Pará (UFOPA), Santarém 68040-255, PA, Brazil.
Juliana Pavan ZulianiLaboratory of Cellular Immunology Applied to Health, Oswaldo Cruz Foundation (FIOCRUZ), Porto Velho 21040-900, RO, Brazil.ORCID 0000-0001-9221-7749
Gemilson Soares PontesLaboratory of Virology and Immunology, Society, Environment and Health Coordination, National Institute of Amazonian Research (INPA), Manaus 69080-001, AM, Brazil.ORCID 0000-0001-9001-7954

Funding

Foundation for Research Support of the State of Amazonas MAECI # 055/2022The Coordination for the Improvement of Higher Education Personnel ( CAPES) #88881.200581/ 2018-01
6 · The paper itself

Abstract

Natural products, especially specific metabolites found in many medicinal plants, exhibit extensive therapeutic potential due to their diverse biological characteristics. Among these compounds, diterpenes stand out for their active principles described in phytochemical studies. Diterpenes exhibit immunomodulatory effects by influencing the production of cytokines and other signaling molecules involved in the immune response. These actions contribute to achieving a more balanced immune profile. The ability to selectively and harmoniously modulate the immune response positions compounds derived from natural products is a promising research field in the development of immunomodulatory therapies. Due to the broad biological activities of diterpenes, the use of molecular docking emerges as a relevant tool for the quantitative screening of a large number of these substances. This review comprehensively examines the pharmacological potential of diterpenes in modulating the immune system. It highlights the existing experimental evidence supporting the efficacy and safety of these compounds as potential treatment for immune dysfunctions. Ultimately, this review aims to contribute to the development of new therapeutic strategies in this field.

Indexed as

DiterpenesImmunologic FactorsImmunomodulating AgentsImmunomodulationAnimalsBiological ProductsCytokinesHumansMolecular Docking SimulationBiological ProductsCytokinesDiterpenesImmunologic FactorsImmunomodulating Agentsimmunomodulatorypharmacological potentialsecondary metabolismterpenes

Identifiers

PMID40076871
PMCPMC11900544

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.