Evidence map›Paper›PMID 40076864›Full record

ReviewInternational journal of molecular sciences2025

Role of Gut Microbial Metabolites in Ischemic and Non-Ischemic Heart Failure.

Mohammad Reza Hatamnejad, Lejla Medzikovic, Ateyeh Dehghanitafti, Bita Rahman, Arjun Vadgama, Mansoureh Eghbali

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mohammad Reza HatamnejadDivision of Molecular Medicine, Department of Anesthesiology and Perioperative Medicine, David Geffen School of Medicine, University of California Los Angeles, BH-550 CHS, Los Angeles, CA 90095-7115, USA.ORCID 0000-0002-2239-5539
Lejla MedzikovicDivision of Molecular Medicine, Department of Anesthesiology and Perioperative Medicine, David Geffen School of Medicine, University of California Los Angeles, BH-550 CHS, Los Angeles, CA 90095-7115, USA.
Ateyeh DehghanitaftiDivision of Molecular Medicine, Department of Anesthesiology and Perioperative Medicine, David Geffen School of Medicine, University of California Los Angeles, BH-550 CHS, Los Angeles, CA 90095-7115, USA.
Bita RahmanDivision of Molecular Medicine, Department of Anesthesiology and Perioperative Medicine, David Geffen School of Medicine, University of California Los Angeles, BH-550 CHS, Los Angeles, CA 90095-7115, USA.
Arjun VadgamaDivision of Molecular Medicine, Department of Anesthesiology and Perioperative Medicine, David Geffen School of Medicine, University of California Los Angeles, BH-550 CHS, Los Angeles, CA 90095-7115, USA.
Mansoureh EghbaliDivision of Molecular Medicine, Department of Anesthesiology and Perioperative Medicine, David Geffen School of Medicine, University of California Los Angeles, BH-550 CHS, Los Angeles, CA 90095-7115, USA.ORCID 0000-0002-6252-9976

Funding

Role of intestinal inflammation in oxidized lipid induced pulmonary hypertensionR01HL162124 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI EGHBALI, MANSOUREH, REDDY, SRINIVASA T. · 2022 to 2025
$2.4M
Role of miR125 in pulmonary hypertension secondary to interstitial lung diseaseR01HL147586 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI EGHBALI, MANSOUREH · 2020 to 2023
$1.9M
Role of Chromosome Y gene, Uty, in protecting against Pulmonary HypertensionR01HL159865 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI EGHBALI, MANSOUREH · 2021 to 2024
$1.9M
ZFP36, an RNA Binding Protein that Regulates DNA Repair and Cell Proliferation in PAHR01HL174472 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Mansoureh Eghbali · 2024 to 2026
$1.2M
American Heart Association 24CDA1263497NHLBI NIH HHS R01 HL147586NHLBI NIH HHS R01 HL159865NHLBI NIH HHS R01 HL162124NHLBI NIH HHS R01 HL174472NIH HHS R01HL147586NIH HHS R01HL159865NIH HHS R01HL162124
6 · The paper itself

Abstract

The effect of the gut microbiota extends beyond their habitant place from the gastrointestinal tract to distant organs, including the cardiovascular system. Research interest in the relationship between the heart and the gut microbiota has recently been emerging. The gut microbiota secretes metabolites, including Trimethylamine N-oxide (TMAO), short-chain fatty acids (SCFAs), bile acids (BAs), indole propionic acid (IPA), hydrogen sulfide (H

Indexed as

Gastrointestinal MicrobiomeHeart FailureMyocardial IschemiaAnimalsHumansHydrogen SulfideMethylaminesSignal TransductionHydrogen SulfideMethylaminestrimethyloxaminebile acidsfecal microbiota transplantationgastrointestinal microbiomegut dysbiosisheart failurehydrogen sulfideprebioticsprobioticsshort-chain fatty acidstrimethylamine N-oxide

Identifiers

PMID40076864
PMCPMC11900495

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.