Evidence map›Paper›PMID 40076860›Full record

ArticleInternational journal of molecular sciences2025

In Vitro and In Silico Cytotoxic Activity of Isocordoin from

Valentina Silva, Evelyn Muñoz, Catalina Ferreira, Alessandra Russo, Joan Villena, Iván Montenegro, Daniela Birchmeier, Alejandro Madrid

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Selective cytotoxicity ofFrontiers in pharmacology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Valentina SilvaLaboratorio de Productos Naturales y Síntesis Orgánica (LPNSO), Facultad de Ciencias Naturales y Exactas, Universidad de Playa Ancha, Leopoldo Carvallo 270, Playa Ancha, Valparaíso 2340000, Chile.ORCID 0009-0007-5422-3735
Evelyn MuñozLaboratorio de Productos Naturales y Síntesis Orgánica (LPNSO), Facultad de Ciencias Naturales y Exactas, Universidad de Playa Ancha, Leopoldo Carvallo 270, Playa Ancha, Valparaíso 2340000, Chile.ORCID 0000-0002-4844-2137
Catalina FerreiraLaboratorio de Productos Naturales y Síntesis Orgánica (LPNSO), Facultad de Ciencias Naturales y Exactas, Universidad de Playa Ancha, Leopoldo Carvallo 270, Playa Ancha, Valparaíso 2340000, Chile.ORCID 0000-0001-5935-6886
Alessandra RussoDepartment of Drug and Health Sciences, University of Catania, V.le A. Doria 6, 95125 Catania, Italy.ORCID 0000-0003-2925-6600
Joan VillenaCenter of Interdisciplinary Biomedical and Engineering Research for Health (MEDING), Escuela de Medicina, Facultad de Medicina, Universidad de Valparaíso, Angamos 655, Reñaca, Viña del Mar 2520000, Chile.ORCID 0000-0003-3336-1454
Iván MontenegroCenter of Interdisciplinary Biomedical and Engineering Research for Health (MEDING), Escuela de Obstetricia y Puericultura, Facultad de Medicina, Universidad de Valparaíso, Angamos 655, Reñaca, Viña del Mar 2520000, Chile.ORCID 0000-0003-4187-951X
Daniela BirchmeierUnidad de Citogenética, Hospital Gustavo Fricke, Avenida Álvarez 1532, Viña del Mar 2520000, Chile.ORCID 0009-0007-2065-3219
Alejandro MadridLaboratorio de Productos Naturales y Síntesis Orgánica (LPNSO), Facultad de Ciencias Naturales y Exactas, Universidad de Playa Ancha, Leopoldo Carvallo 270, Playa Ancha, Valparaíso 2340000, Chile.ORCID 0000-0001-8977-7032

Funding

Fondecyt 1230311
6 · The paper itself

Abstract

This study investigates the anticancer potential of isocordoin, a prenylated chalcone found in

Indexed as

Antineoplastic AgentsAntineoplastic Agents, PhytogenicChalconesApoptosisCaspase 3Cell Line, TumorCell SurvivalComputer SimulationHT29 CellsHumansMCF-7 CellsMembrane Potential, MitochondrialMolecular Docking SimulationAntineoplastic AgentsAntineoplastic Agents, PhytogenicCaspase 3ChalconesAdesmia balsamicaapoptosiscaspasecytotoxicisocordoinmolecular docking

Identifiers

PMID40076860
PMCPMC11900625

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.