Evidence map›Paper›PMID 40076801›Full record

ArticleInternational journal of molecular sciences2025

A Leg Cuticle Protein Enhances the Resistance of

Lin Li, Ling Gu, Lei Tu, Si-Jia Deng, Ju-Ping Hu, Zi-Ye Zhang, Ju-Lin Li, Mei-Chun Zhang, Jun Cao, Jian-Xia Tang and 1 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Lin LiSchool of Public Health, Nanjing Medical University, Nanjing 211166, China.
Ling GuSchool of Public Health, Nanjing Medical University, Nanjing 211166, China.ORCID 0009-0007-7377-7506
Lei TuWuxi School of Medicine, Jiangnan University, Wuxi 214122, China.
Si-Jia DengNational Health Commission Key Laboratory of Parasitic Disease Control and Prevention, Jiangsu Provincial Key Laboratory on Parasite and Vector Control Technology, Jiangsu Provincial Medical Key Laboratory, Jiangsu Institute of Parasitic Diseases, Wuxi 214064, China.ORCID 0009-0002-8920-698X
Ju-Ping HuNational Health Commission Key Laboratory of Parasitic Disease Control and Prevention, Jiangsu Provincial Key Laboratory on Parasite and Vector Control Technology, Jiangsu Provincial Medical Key Laboratory, Jiangsu Institute of Parasitic Diseases, Wuxi 214064, China.
Zi-Ye ZhangSchool of Public Health, Nanjing Medical University, Nanjing 211166, China.
Ju-Lin LiNational Health Commission Key Laboratory of Parasitic Disease Control and Prevention, Jiangsu Provincial Key Laboratory on Parasite and Vector Control Technology, Jiangsu Provincial Medical Key Laboratory, Jiangsu Institute of Parasitic Diseases, Wuxi 214064, China.
Mei-Chun ZhangNational Health Commission Key Laboratory of Parasitic Disease Control and Prevention, Jiangsu Provincial Key Laboratory on Parasite and Vector Control Technology, Jiangsu Provincial Medical Key Laboratory, Jiangsu Institute of Parasitic Diseases, Wuxi 214064, China.
Jun CaoSchool of Public Health, Nanjing Medical University, Nanjing 211166, China.ORCID 0000-0001-5298-9234
Jian-Xia TangSchool of Public Health, Nanjing Medical University, Nanjing 211166, China.
Guo-Ding ZhuSchool of Public Health, Nanjing Medical University, Nanjing 211166, China.

Funding

Key Research and Development Program sponsored by the Ministry of Science and Tech-nology (MOST),National Natural Science Foundation of China and the Bill and Melinda Gates Foundation (2023YFA1801004)(82261128002, 2022YFML1003)
6 · The paper itself

Abstract

Insecticide resistance in mosquitoes has become a severe impediment to global vector control and manifests as decreased insecticide effectiveness. The role of target site mutations and detoxification enzymes as resistance markers has been documented in mosquitoes; however, the emergence of complex resistant phenotypes suggest the occurrence of additional mechanisms. Cuticular proteins (CPs) are key constituents of the insect cuticle, and play critical roles in insect development and insecticide resistance. In this study, via electron microscopy we observed that the leg cuticle thickness in deltamethrin-resistant (DR)

Indexed as

AnophelesInsecticide ResistanceInsecticidesInsect ProteinsNitrilesPyrethrinsAnimalsExtremitiesRNA Interferencecuticle proteins, insectsdecamethrinInsecticidesInsect ProteinsNitrilesPyrethrinsanophelinescuticle thickeningdecreased penetrationpyrethroid resistanceRNAi

Identifiers

PMID40076801
PMCPMC11900137

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.