ReviewInternational journal of molecular sciences2025
Modified Cortisol Circadian Rhythm: The Hidden Toll of Night-Shift Work.
Review in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association between circadian rhythm disturbances and cognitive decline in the elderly: a systematic review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Pooled it
- Selective and Fast Cortisol Sensing in Human Saliva Using Graphene-Based On-Chip Field-Effect Transistors.Small science · 2026Article
- Exercise-induced neuropeptidergic and neurochemical neuroadaptation in stress regulation and emotional disorders.Acta neurologica Belgica · 2026Review
- Sleep Duration and Sun Exposure in Portuguese Children: Associations With Obesity Indicators.American journal of human biology : the official journal of the Human Biology Council · 2026Article
- The Interactions Between Circadian Rhythm, Gut Microbiota, and Anxiety: From Mechanisms to Intervention Strategies.Nutrients · 2026Review
- Salivary Cortisol Response After Ropivacaine-Dexamethasone Administration: A Randomized Clinical Trial.Pharmaceuticals (Basel, Switzerland) · 2026Article
- Importance ranking and predictive model construction of WMSDs risk factors among shift-working nurses based on multiple machine-learning algorithms.BMC nursing · 2026Article
- Cardiovascular Risk and Modifiable Risk Factors in Shift-Working Healthcare Workers: A Gender-Stratified Cross-Sectional Study.Journal of clinical medicine · 2026Article
- Effects of Shift Work Type on Sleep Quality and Cortisol Regulation Among Nurses: A Prospective Observational Study.International journal of environmental research and public health · 2026Observational
- Retinal ganglion cell degeneration in glaucoma disrupts HPA axis temporal organization and dampens corticosterone production.Journal of neuroendocrinology · 2026Article
- Article
- Behavioral-Gastrointestinal Interaction Between Night Eating Syndrome and GERD Among Saudi Adults: Implications for Clinical Screening and Lifestyle-Based Care.Healthcare (Basel, Switzerland) · 2026Article
- Do Long-Haul Travel and Jet Lag Affect Athletes' Physiological, Humoral and Performance Outcomes? A Systematic Narrative Review.Sports (Basel, Switzerland) · 2026Review
- A Maturation-Aware Machine Learning Framework for Screening the Nutritional Status of Adolescents.Nutrients · 2026Article
- When the biological clock is disordered: circadian rhythm disruption as a core pathophysiological mechanism in anxiety and depression.Frontiers in psychiatry · 2026Review
- Adaptive changes in adrenal steroid metabolism under extreme physical and psychological stress: a narrative review.Frontiers in endocrinology · 2026Review
- Association between night-shift frequency and metabolic syndrome among healthcare workers: a moderated mediation analysis of occupational stress and sleep quality.Frontiers in public health · 2026Article
- Inflammatory marker dynamics in shift work sleep disorder: a data-driven approach among rotating shift workers.Frontiers in neuroscience · 2026Article
- Endocrine-related osteoporosis: the state of the art.Frontiers in endocrinology · 2026Review
- Non-chemical, chemical, and biochemical, endocrine disruptors: biphasic health effects and pathophysiological insights.Frontiers in endocrinology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The circadian rhythm of cortisol, a key hormone essential for maintaining metabolic balance and stress homeostasis, is profoundly disrupted by night-shift work. This narrative review examines the physiological mechanisms underlying cortisol regulation, the effects of shift work on its circadian rhythm, the associated health risks, and potential mitigation strategies. Night-shift work alters the natural secretion pattern of cortisol, leading to dysregulation of the hypothalamic-pituitary-adrenal axis, which in turn can contribute to metabolic disorders, cardiovascular diseases, and impaired cognitive function. Understanding the physiological pathways mediating these changes is crucial for developing targeted interventions to mitigate the adverse effects of circadian misalignment. Potential strategies, such as controlled light exposure, strategic napping, and personalized scheduling, may help to stabilize cortisol rhythms and improve health outcomes. This review aims to provide insights that can guide future research and inform occupational health policies for night-shift workers by addressing these challenges.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.