Evidence map›Paper›PMID 40076714›Full record

ArticleInternational journal of molecular sciences2025

Bitter Taste Receptors 38 and 46 Regulate Intestinal Peristalsis.

Lara Camillo, Federica Pollastro, Maria Talmon, Luigia Grazia Fresu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Lara CamilloDepartment of Health Sciences, University of Piemonte Orientale, 28100 Novara, Italy.ORCID 0000-0003-2148-3454
Federica PollastroDepartment of Pharmaceutical Sciences, University of Piemonte Orientale, 28100 Novara, Italy.ORCID 0000-0002-0949-2799
Maria TalmonDepartment of Pharmaceutical Sciences, University of Piemonte Orientale, 28100 Novara, Italy.
Luigia Grazia FresuDepartment of Health Sciences, University of Piemonte Orientale, 28100 Novara, Italy.ORCID 0000-0002-8605-9040

Funding

Ministero dell'Università e della Ricerca, Prin 2022 2022F7K7RY
6 · The paper itself

Abstract

Bitter taste receptors (TAS2Rs) are expressed in extraoral tissues, exerting several functions and generating a whole-body chemosensory and protective system. TAS2Rs expression has been observed in the gastrointestinal tract, although their role is poorly understood. This study aims to investigate the role of TAS2R38 and 46 in human intestinal smooth muscle cells (HISMCs) after activation with the specific bitter ligands phenylthiocarbamide and absinthin, respectively. We found that TAS2R38 and 46 activation by phenylthiocarbamide (PTC) and absinthin, respectively, induces a rapid membrane depolarization and increase of cytosolic calcium levels due to internal storage in the IP

Indexed as

IntestinesPeristalsisReceptors, G-Protein-CoupledCalciumHumansMuscle ContractionMyocytes, Smooth MusclePhenylthioureaTasteTaste Receptors, Type 2CalciumPhenylthioureaReceptors, G-Protein-CoupledTaste Receptors, Type 2absinthinbitter taste receptorcalciumgut peristalsisinflammationPTC

Identifiers

PMID40076714
PMCPMC11900946

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.