Evidence map›Paper›PMID 40076704›Full record

ArticleInternational journal of molecular sciences2025

Rotenone Induces Parkinsonism with Constipation Symptoms in Mice by Disrupting the Gut Microecosystem, Inhibiting the PI3K-AKT Signaling Pathway and Gastrointestinal Motility.

Li Liu, Yan Zhao, Weixing Yang, Yuqin Fan, Lixiang Han, Jun Sheng, Yang Tian, Xiaoyu Gao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Li LiuYunnan Key Laboratory of Precision Nutrition and Personalized Food Manufacturing, Yunnan Agricultural University, Kunming 650201, China.
Yan ZhaoDivision of Science and Technology, Yunnan Agricultural University, Kunming 650201, China.
Weixing YangCollege of Food Science and Technology, Yunnan Agricultural University, Kunming 650201, China.
Yuqin FanCollege of Food Science and Technology, Yunnan Agricultural University, Kunming 650201, China.
Lixiang HanCollege of Food Science and Technology, Yunnan Agricultural University, Kunming 650201, China.
Jun ShengYunnan Key Laboratory of Precision Nutrition and Personalized Food Manufacturing, Yunnan Agricultural University, Kunming 650201, China.
Yang TianYunnan Key Laboratory of Precision Nutrition and Personalized Food Manufacturing, Yunnan Agricultural University, Kunming 650201, China.
Xiaoyu GaoYunnan Key Laboratory of Precision Nutrition and Personalized Food Manufacturing, Yunnan Agricultural University, Kunming 650201, China.ORCID 0009-0003-1468-8184

Funding

Xingdian talent plan of Yunnan Province Young talents project, 2022-0255Yunnan Fundamental Research Projects 202401AT070217Yunnan Province-City Integration Project 202302AN360002
6 · The paper itself

Abstract

Parkinson's disease (PD) is one of the most common neurodegenerative diseases. Constipation is a prodromal symptom of PD. It is important to investigate the pathogenesis of constipation symptoms in PD. Rotenone has been successfully used to establish PD animal models. However, the specific mechanism of rotenone-induced constipation symptoms is not well understood. In this work, we found that constipation symptoms appeared earlier than motor impairment in mice gavaged with a low dose of rotenone (30 mg/kg·BW). Rotenone not only caused loss of dopaminergic neurons and accumulation of α-synuclein, but also significantly reduced serum 5-HT levels and

Indexed as

Brain-Gut AxisConstipationGastrointestinal MicrobiomeParkinsonian DisordersRotenoneAnimalsBlood-Brain BarrierColonDisease Models, AnimalDopaminergic NeuronsGastrointestinal MotilityMaleMiceMice, Inbred C57BLPhosphatidylinositol 3-KinasesProdromal SymptomsPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktRotenoneAcinetobacterAkkermansiabarrierBifidobacteriumconstipationEubacterium xylanophilum-groupgut microbiotainflammationLactobacillusmovement disordersnon-motor symptomsSolibacillusStaphylococcus

Identifiers

PMID40076704
PMCPMC11899888

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.