Evidence map›Paper›PMID 40076688›Full record

ArticleInternational journal of molecular sciences2025

Antioxidant, Antidiabetic, and Vasorelaxant Effects of Ethanolic Extract from the Seeds of

Elizabeth Alejandrina Guzmán Hernández, Gladys Chirino Galindo, Rubén San Miguel Chávez, Patricia Castro Moreno, Maximiliano Ibarra Barajas, Tomás Ernesto Villamar Duque, Anayantzin Paulina Heredia Antúnez, Leonardo Del Valle Mondragón, Gil Alfonso Magos Guerrero, David Segura Cobos

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Elizabeth Alejandrina Guzmán HernándezMedical Surgeon Career, Faculty of Higher Studies Iztacala, National Autonomous University of Mexico, Tlalnepantla C.P. 54090, Mexico.
Gladys Chirino GalindoDiabetes Mellitus Metabolism Laboratory, Faculty of Higher Studies Iztacala, National Autonomous University of Mexico, Tlalnepantla C.P. 54090, Mexico.
Rubén San Miguel ChávezPhytochemistry Area, Postgraduate in Botany, Postgraduate College, Mexico City 11340, Mexico.
Patricia Castro MorenoBiomedicine Unit, Faculty of Higher Studies Iztacala, National Autonomous University of Mexico, Tlalnepantla C.P. 54090, Mexico.
Maximiliano Ibarra BarajasBiomedicine Unit, Faculty of Higher Studies Iztacala, National Autonomous University of Mexico, Tlalnepantla C.P. 54090, Mexico.
Tomás Ernesto Villamar DuqueGeneral Bioterium, Faculty of Higher Studies Iztacala, Biology, National Autonomous University of Mexico (UNAM), Tlalnepantla C.P. 54090, Mexico.ORCID 0000-0002-6094-7314
Anayantzin Paulina Heredia AntúnezGeneral Bioterium, Faculty of Higher Studies Iztacala, Biology, National Autonomous University of Mexico (UNAM), Tlalnepantla C.P. 54090, Mexico.ORCID 0009-0003-2188-7309
Leonardo Del Valle MondragónDepartment of Pharmacology, National Institute of Cardiology Ignacio Chavez, Mexico City 04510, Mexico.ORCID 0000-0002-2999-1050
Gil Alfonso Magos GuerreroDepartment of Pharmacology, Faculty of Medicine, University National Autonomous of Mexico (UNAM), Mexico City 04510, Mexico.
David Segura CobosMedical Surgeon Career, Faculty of Higher Studies Iztacala, National Autonomous University of Mexico, Tlalnepantla C.P. 54090, Mexico.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Arterial hypertension and diabetes mellitus are components of the cardiometabolic syndrome that arises from a sedentary lifestyle, excess calorie intake, and obesity. Swietenia humilis Zucc has been used in traditional Mexican medicine for the treatment of diabetes mellitus; this work investigated the antioxidant, antidiabetic, and vasorelaxant effects of ethanolic extract of S. humilis seeds. The phytochemical composition of the extract was analyzed by high-performance liquid chromatography. To study the hypoglycemic effect, the activity of antioxidant enzymes (catalase, superoxide dismutase, and glutathione peroxidase) and markers of oxidative stress (malondialdehyde and 8-hydroxy-2-desoxyguanosine) were evaluated in the model of diabetes mellitus induced by nicotinamide and streptozotocin in rats. The vasodilatory effect of the extract was tested in rat aortic rings. The ethanolic extract of seeds of Swietenia humilis showed antioxidant, hypoglycemic, and endothelium-independent vasorelaxant effects, probably by blocking calcium transport, likely due to ursolic acid and α-amyrin, phytochemical compounds more abundant in the extract.

Indexed as

AntioxidantsDiabetes Mellitus, ExperimentalHypoglycemic AgentsMeliaceaePlant ExtractsSeedsVasodilator AgentsAnimalsAortaEthanolMaleOxidative StressRatsRats, WistarAntioxidantsEthanolHypoglycemic AgentsPlant ExtractsVasodilator Agentsantidiabetic plantantihypertensive plantsSwietenia humilis

Identifiers

PMID40076688
PMCPMC11900308

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.