Evidence map›Paper›PMID 40076669›Full record

ArticleInternational journal of molecular sciences2025

Genetic Variants in Genes Related to Lung Function and Interstitial Lung Diseases Are Associated with Worse Outcomes in Severe COVID-19 and Lung Performance in the Post-COVID-19 Condition.

Ingrid Fricke-Galindo, Salvador García-Carmona, Brandon Bautista-Becerril, Gloria Pérez-Rubio, Ivette Buendia-Roldan, Leslie Chávez-Galán, Karol J Nava-Quiroz, Jesús Alanis-Ponce, Juan M Reséndiz-Hernández, Esther Blanco-Aguilar and 7 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Ingrid Fricke-GalindoHLA Laboratory, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City 14080, Mexico.ORCID 0000-0003-2132-1076
Salvador García-CarmonaHLA Laboratory, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City 14080, Mexico.ORCID 0000-0002-5195-7385
Brandon Bautista-BecerrilHLA Laboratory, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City 14080, Mexico.ORCID 0000-0001-5975-6724
Gloria Pérez-RubioHLA Laboratory, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City 14080, Mexico.ORCID 0000-0002-6876-1012
Ivette Buendia-RoldanTranslational Research Laboratory on Aging and Pulmonary Fibrosis, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City 14080, Mexico.ORCID 0000-0002-2825-506X
Leslie Chávez-GalánLaboratory of Integrative Immunology, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City 14080, Mexico.ORCID 0000-0002-2334-0361
Karol J Nava-QuirozHLA Laboratory, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City 14080, Mexico.ORCID 0000-0003-4418-2646
Jesús Alanis-PonceHLA Laboratory, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City 14080, Mexico.ORCID 0000-0001-9902-7470
Juan M Reséndiz-HernándezLaboratorio Clínico, Centro Especializado de Atención a Personas con Discapacidad Visual, Instituto de Salud del Estado de México, Naucalpan 53000, Mexico State, Mexico.
Esther Blanco-AguilarFacultad de Medicina Benemérita, Universidad Autónoma de Puebla, Puebla de Zaragoza 72420, Puebla, Mexico.
Jessica I Erives-SedanoInstituto de Ciencias Biomédicas, Universidad Autónoma de Ciudad Juárez, Ciudad Juárez 32310, Chihuahua, Mexico.ORCID 0009-0003-5371-3522
Yashohara Méndez-VelascoUnidad Académica Profesional Chimalhuacán, Universidad Autónoma del Estado de México, Nezahualcóyotl 56353, Mexico State, Mexico.ORCID 0009-0009-0330-947X
Grecia E Osuna-EspinozaFacultad de Ciencias Químico Biológicas, Universidad Autónoma de Sinaloa, Culiacán Rosales 80030, Sinaloa, Mexico.ORCID 0009-0007-1399-1543
Fidel Salvador-HernándezEscuela Nacional de Medicina y Homeopatía, Instituto Politécnico Nacional, Mexico City 07320, Mexico.
Rubén Segura-CastañedaFacultad Interdisciplinaria de Ciencias Biológicas y de Salud, Universidad de Sonora, Hermosillo Sonora 83000, Sonora, Mexico.ORCID 0009-0002-9788-0069
Uriel N Solano-CandiaFacultad de Biología, Universidad Michoacana de San Nicolás de Hidalgo, Morelia 58000, Michoacán, Mexico.ORCID 0009-0006-2774-1492
Ramcés Falfán-ValenciaHLA Laboratory, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City 14080, Mexico.ORCID 0000-0001-6877-8124

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Genetic variants related to susceptibility to chronic respiratory conditions such as interstitial lung disease (ILD) could share critical pathways in the pathogenesis of COVID-19 and be implicated in COVID-19 outcomes and post-COVID-19. We aimed to identify the participation of genetic variants in lung function and ILD genes in severe COVID-19 outcomes and post-COVID-19 condition. We studied 936 hospitalized patients with COVID-19. The requirement of invasive mechanical ventilation (IMV) and the acute respiratory distress syndrome (ARDS) classification were considered. The mortality was assessed as the in-hospital death. The post-COVID-19 group included 102 patients evaluated for pulmonary function tests four times during the year after discharge. Five variants (

Indexed as

COVID-19LungLung Diseases, InterstitialAgedFemaleGenetic Predisposition to DiseaseGTPase-Activating ProteinsHumansIntracellular Signaling Peptides and ProteinsMaleMiddle AgedPolymorphism, Single NucleotideRespiratory Distress SyndromeRespiratory Function TestsSARS-CoV-2Severity of Illness IndexFAM13A protein, humanGTPase-Activating ProteinsIntracellular Signaling Peptides and ProteinsTOLLIP protein, humanCOVID-19DSPFAM13Ainterstitial lung diseasesinvasive mechanical ventilationpost-COVID-19pulmonary functionTERTTHSD4

Identifiers

PMID40076669
PMCPMC11900979

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.