Evidence map›Paper›PMID 40076642›Full record

ArticleInternational journal of molecular sciences2025

Unveiling the Mechanism of Action of Palmitic Acid, a Human Topoisomerase 1B Inhibitor from the Antarctic Sponge

Alessio Ottaviani, Davide Pietrafesa, Bini Chhetri Soren, Jagadish Babu Dasari, Stine S H Olsen, Beatrice Messina, Francesco Demofonti, Giulia Chicarella, Keli Agama, Yves Pommier and 6 more

Abstract read
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In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Alessio OttavianiDepartment of Onco-Hematology, Gene and Cell Therapy, Bambino Gesù Children's Hospital-IRCCS, Via Ferdinando Baldelli 38, 00146 Rome, Italy.
Davide PietrafesaDepartment of Biology, University of Rome Tor Vergata, Via della Ricerca Scientifica, 00133 Rome, Italy.ORCID 0009-0009-5154-6154
Bini Chhetri SorenDepartment of Biology, University of Rome Tor Vergata, Via della Ricerca Scientifica, 00133 Rome, Italy.
Jagadish Babu DasariDepartment of Biology, University of Rome Tor Vergata, Via della Ricerca Scientifica, 00133 Rome, Italy.
Stine S H OlsenDepartment of Chemistry, University of South Florida, USF Sweetgum Ln 12111, Tampa, FL 33620, USA.ORCID 0009-0001-4621-6291
Beatrice MessinaDepartment of Biology, University of Rome Tor Vergata, Via della Ricerca Scientifica, 00133 Rome, Italy.
Francesco DemofontiDepartment of Biology, University of Rome Tor Vergata, Via della Ricerca Scientifica, 00133 Rome, Italy.
Giulia ChicarellaDepartment of Biology, University of Rome Tor Vergata, Via della Ricerca Scientifica, 00133 Rome, Italy.
Keli AgamaLaboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, Convent Drive 37, Bethesda, MD 20892, USA.ORCID 0000-0002-0505-8645
Yves PommierLaboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, Convent Drive 37, Bethesda, MD 20892, USA.
Blasco Morozzo Della RoccaDepartment of Biology, University of Rome Tor Vergata, Via della Ricerca Scientifica, 00133 Rome, Italy.ORCID 0000-0001-5491-1131
Federico IacovelliDepartment of Biology, University of Rome Tor Vergata, Via della Ricerca Scientifica, 00133 Rome, Italy.ORCID 0000-0001-7511-6575
Alice RomeoDepartment of Biology, University of Rome Tor Vergata, Via della Ricerca Scientifica, 00133 Rome, Italy.ORCID 0000-0001-6162-6814
Mattia FalconiDepartment of Biology, University of Rome Tor Vergata, Via della Ricerca Scientifica, 00133 Rome, Italy.ORCID 0000-0002-3990-4758
Bill J BakerDepartment of Chemistry, University of South Florida, USF Sweetgum Ln 12111, Tampa, FL 33620, USA.ORCID 0000-0003-3033-5779
Paola FioraniDepartment of Biology, University of Rome Tor Vergata, Via della Ricerca Scientifica, 00133 Rome, Italy.

Funding

MIUR PNRA18_00005 - Linea D
6 · The paper itself

Abstract

Cancer remains a leading cause of death worldwide, highlighting the urgent need for novel and more effective treatments. Natural products, with their structural diversity, represent a valuable source for the discovery of anticancer compounds. In this study, we screened 750 Antarctic extracts to identify potential inhibitors of human topoisomerase 1 (hTOP1), a key enzyme in DNA replication and repair, and a target of cancer therapies. Bioassay-guided fractionation led to the identification of palmitic acid (PA) as the active compound from the Antarctic sponge

Indexed as

DNA Topoisomerases, Type IPalmitic AcidPoriferaTopoisomerase I InhibitorsAnimalsAntarctic RegionsDNAHumansMolecular Dynamics SimulationDNADNA Topoisomerases, Type IPalmitic AcidTOP1 protein, humanTopoisomerase I InhibitorsAntarctic extractshuman DNA topoisomerasemolecular dynamicpalmitic acid

Identifiers

PMID40076642
PMCPMC11900379

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.