Evidence map›Paper›PMID 40076621›Full record

ArticleInternational journal of molecular sciences2025

Establishment of a Novel In Vitro and In Vivo Model to Understand Molecular Carcinogenesis of Endometriosis-Related Ovarian Neoplasms.

Hasibul Islam Sohel, Tohru Kiyono, Umme Farzana Zahan, Sultana Razia, Masako Ishikawa, Hitomi Yamashita, Kosuke Kanno, Shahataj Begum Sonia, Kentaro Nakayama, Satoru Kyo

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hasibul Islam SohelDepartment of Obstetrics and Gynecology, Faculty of Medicine, Shimane University, Izumo 693-8501, Japan.ORCID 0009-0008-8987-9686
Tohru KiyonoExploratory Oncology Research and Clinical Trial Center (EPOC), National Cancer Center, Kashiwa 277-8577, Japan.ORCID 0000-0003-1769-403X
Umme Farzana ZahanDepartment of Obstetrics and Gynecology, Faculty of Medicine, Shimane University, Izumo 693-8501, Japan.ORCID 0009-0008-7147-8569
Sultana RaziaDepartment of Legal Medicine, Shimane University Faculty of Medicine, 89-1 Enya-Cho, Izumo 693-8501, Japan.
Masako IshikawaDepartment of Obstetrics and Gynecology, Faculty of Medicine, Shimane University, Izumo 693-8501, Japan.
Hitomi YamashitaDepartment of Obstetrics and Gynecology, Faculty of Medicine, Shimane University, Izumo 693-8501, Japan.
Kosuke KannoDepartment of Obstetrics and Gynecology, Faculty of Medicine, Shimane University, Izumo 693-8501, Japan.
Shahataj Begum SoniaDepartment of Obstetrics and Gynecology, Faculty of Medicine, Shimane University, Izumo 693-8501, Japan.ORCID 0009-0005-9983-5810
Kentaro NakayamaDepartment of Obstetrics and Gynecology, East Medical Center, Nagoya City University, Nagoya 464-8547, Japan.ORCID 0000-0002-3250-3097
Satoru KyoDepartment of Obstetrics and Gynecology, Faculty of Medicine, Shimane University, Izumo 693-8501, Japan.ORCID 0000-0002-8986-6147

Funding

JSPS KAKENHI 24K02588
6 · The paper itself

Abstract

The molecular mechanisms through which endometriosis-related ovarian neoplasms (ERONs) develop from benign endometrioma remain unclear. It is especially a long-standing mystery why ovarian endometrioma has the potential to develop into two representative histological subtypes: endometrioid ovarian carcinoma or clear cell ovarian carcinoma. This study aimed to investigate the molecular carcinogenesis of ERONs using newly developed in vitro and in vivo carcinogenesis models. Epithelial cells were isolated and purified from surgically removed benign endometrioma samples, followed by immortalization by overexpressing

Indexed as

CarcinogenesisEndometriosisOvarian NeoplasmsAnimalsCell Transformation, NeoplasticDisease Models, AnimalDNA-Binding ProteinsFemaleHumansMiceProto-Oncogene Proteins p21(ras)Transcription FactorsARID1A protein, humanDNA-Binding ProteinsProto-Oncogene Proteins p21(ras)Transcription Factorscarcinogenesisclear cell carcinomaendometrioid carcinomaendometriosisERONstumor immune microenvironment

Identifiers

PMID40076621
PMCPMC11901000

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.