Evidence map›Paper›PMID 40076572›Full record

ArticleInternational journal of molecular sciences2025

Exploring the Potential of Coumarin Derivatives on Serotonin Receptors 5-HT

Kinga Ostrowska, Gabriela Horosz, Karolina Kruk, Bartłomiej Sieroń, Anna Leśniak, Zofia Czartoryska, Magdalena Bujalska-Zadrożny, Dejan Milenkovic, Bartosz Trzaskowski

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kinga OstrowskaDepartment of Organic and Physical Chemistry, Faculty of Pharmacy, Medical University of Warsaw, Banacha 1, 02-097 Warsaw, Poland.ORCID 0000-0002-5990-646X
Gabriela HoroszDepartment of Organic and Physical Chemistry, Faculty of Pharmacy, Medical University of Warsaw, Banacha 1, 02-097 Warsaw, Poland.
Karolina KrukDepartment of Organic and Physical Chemistry, Faculty of Pharmacy, Medical University of Warsaw, Banacha 1, 02-097 Warsaw, Poland.
Bartłomiej SierońDepartment of Organic and Physical Chemistry, Faculty of Pharmacy, Medical University of Warsaw, Banacha 1, 02-097 Warsaw, Poland.
Anna LeśniakFaculty of Pharmacy, Department of Pharmacotherapy and Pharmaceutical Care, Medical University of Warsaw, Banacha 1, 02-097 Warsaw, Poland.ORCID 0000-0002-6014-9208
Zofia CzartoryskaFaculty of Pharmacy, Department of Pharmacotherapy and Pharmaceutical Care, Medical University of Warsaw, Banacha 1, 02-097 Warsaw, Poland.
Magdalena Bujalska-ZadrożnyFaculty of Pharmacy, Department of Pharmacotherapy and Pharmaceutical Care, Medical University of Warsaw, Banacha 1, 02-097 Warsaw, Poland.
Dejan MilenkovicDepartment of Science, Institute for Information Technologies, University of Kragujevac, Jovana Cvijića bb, 34000 Kragujevac, Serbia.ORCID 0000-0001-7083-2257
Bartosz TrzaskowskiCentre of New Technologies, University of Warsaw, 2C Banacha Str., 02-097 Warsaw, Poland.ORCID 0000-0003-2385-1476

Funding

Medical University of Warsaw WF7/4/F/MG/N/24
6 · The paper itself

Abstract

A series of 2- and 3-methoxyphenylpiperazine derivatives in combination with a 2-hydroxypropoxy linker and coumarins containing various substituents was synthesized and evaluated for antidepressant-like activity. Microwave-assisted synthesis was used, and the structures of all compounds were confirmed by

Indexed as

Antidepressive AgentsCoumarinsReceptor, Serotonin, 5-HT1AReceptor, Serotonin, 5-HT2AAnimalsHumansMolecular Docking SimulationStructure-Activity RelationshipAntidepressive AgentsCoumarinsReceptor, Serotonin, 5-HT1AReceptor, Serotonin, 5-HT2A5HT1A5HT2A receptors ligandscoumarin derivativesmicrowave-assisted synthesismolecular docking

Identifiers

PMID40076572
PMCPMC11900313

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.