Evidence map›Paper›PMID 40076539›Full record

ArticleInternational journal of molecular sciences2025

Tumor Regulatory Effect of 15-Hydroxyprostaglandin Dehydrogenase (HPGD) in Triple-Negative Breast Cancer.

Joselyn Padilla, Bok-Soon Lee, Allen Kim, Yea-In Park, Avani Bansal, Jiyoung Lee

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Validation of Prognostic Circulating Cell-Free RNA BiomarkersCurrent issues in molecular biology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Joselyn PadillaDepartment of Biochemistry and Molecular Medicine, School of Medicine and Health Sciences, The George Washington University, Washington, DC 20037, USA.ORCID 0000-0002-1898-1041
Bok-Soon LeeDepartment of Biochemistry and Molecular Medicine, School of Medicine and Health Sciences, The George Washington University, Washington, DC 20037, USA.
Allen KimDepartment of Biochemistry and Molecular Medicine, School of Medicine and Health Sciences, The George Washington University, Washington, DC 20037, USA.
Yea-In ParkDepartment of Biochemistry and Molecular Medicine, School of Medicine and Health Sciences, The George Washington University, Washington, DC 20037, USA.ORCID 0000-0002-7851-8470
Avani BansalDepartment of Biochemistry and Molecular Medicine, School of Medicine and Health Sciences, The George Washington University, Washington, DC 20037, USA.
Jiyoung LeeDepartment of Biochemistry and Molecular Medicine, School of Medicine and Health Sciences, The George Washington University, Washington, DC 20037, USA.ORCID 0000-0001-8503-4805

Funding

Understanding lactate catabolism by BACH1 in triple negative breast cancerR37CA270536 · NCI · GEORGE WASHINGTON UNIVERSITY · PI Jiyoung Lee · 2022 to 2026
$2.4M
NCI NIH HHS R37 CA270536NIH HHS 1R37CA270536-22A1
6 · The paper itself

Abstract

Prostaglandin regulation is known to play a pivotal role in tumorigenesis; however, the contributions of the prostaglandin-metabolizing enzyme 15-hydroxyprostaglandin dehydrogenase (HPGD) to cancer development remain poorly understood. In this study, we investigate the effects of HPGD on cell viability, proliferation, anchorage-independent growth, and migration in triple-negative breast cancer (TNBC), an aggressive subtype of breast cancer. Overexpression of HPGD in human TNBC cells resulted in both positive and negative regulation of cell proliferation and colony formation, with these effects occurring independent of prostaglandin E2 (PGE

Indexed as

Hydroxyprostaglandin DehydrogenasesTriple Negative Breast NeoplasmsAnimalsCell Line, TumorCell MovementCell ProliferationCell SurvivalDinoprostoneFemaleGene Expression Regulation, NeoplasticHumansMiceSignal Transduction15-hydroxyprostaglandin dehydrogenaseDinoprostoneHydroxyprostaglandin Dehydrogenases15-hydroxyprostaglandin dehydrogenaseHPGDPDGHProstaglandintriple-negative breast cancer

Identifiers

PMID40076539
PMCPMC11899648

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.