Evidence map›Paper›PMID 40076531›Full record

ArticleInternational journal of molecular sciences2025

A Two-Hour Fetal Glucagon Infusion Stimulates Hepatic Catabolism of Amino Acids in Fetal Sheep.

Amelia R Tanner, Sarah N Cilvik, Marjorie A Nguyen, Evgenia Dobrinskikh, Russell V Anthony, Stephanie R Wesolowski, Paul J Rozance

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Amelia R TannerPerinatal Research Center, Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO 80045, USA.ORCID 0000-0003-0326-7096
Sarah N CilvikDepartment of Pediatrics, Wake Forest University School of Medicine, Winston-Salem, NC 27101, USA.ORCID 0000-0003-4673-1186
Marjorie A NguyenPerinatal Research Center, Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO 80045, USA.ORCID 0000-0002-6191-8283
Evgenia DobrinskikhPerinatal Research Center, Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO 80045, USA.
Russell V AnthonyDepartment of Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA.ORCID 0000-0003-3929-626X
Stephanie R WesolowskiPerinatal Research Center, Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO 80045, USA.
Paul J RozancePerinatal Research Center, Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO 80045, USA.

Funding

University of Colorado Anschutz Medical Campus DRCP30DK116073 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI Maki Nakayama · 2020 to 2026
$10.8M
Training Program in Perinatal Biology and MedicineT32HD007186 · NICHD · UNIVERSITY OF COLORADO DENVER · PI Paul Joseph Rozance · 1985 to 2026
$6.5M
Physiological Ramifications of Chorionic Somatomammotropin DeficiencyR01HD093701 · NICHD · UNIVERSITY OF COLORADO DENVER · PI ANTHONY, RUSSELL V, ROZANCE, PAUL JOSEPH · 2018 to 2022
$2.9M
Fetal glucagon links fetal metabolism with uterine blood flow and placental nutrient transfer by inhibiting placental lactogen secretionR01HD111557 · NICHD · UNIVERSITY OF COLORADO DENVER · PI Paul Joseph Rozance · 2023 to 2026
$2.5M
UV-visible HPLC with PCX Pinnacle post column reaction moduleS10OD023553 · OD · UNIVERSITY OF COLORADO DENVER · PI BROWN, LAURA DAVIDSON · 2017 to 2017
$98k
NICHD NIH HHS R01 HD093701NICHD NIH HHS R01 HD111557NICHD NIH HHS T32 HD007186NIDDK NIH HHS P30 DK116073NIH HHS P30-DK116073NIH HHS R01HD093701NIH HHS R01HD111557NIH HHS S10 OD023553NIH HHS S10OD023553NIH HHS T32HD007186
6 · The paper itself

Abstract

Postnatally, glucagon acutely lowers plasma amino acid (AA) concentrations by stimulating hepatic AA catabolism, but its fetal actions remain unclear. This study tested whether a 2 h fetal glucagon infusion would stimulate hepatic AA catabolism and inhibit placental AA transfer. Late-gestation pregnant sheep (0.9 gestation) underwent surgical, vascular catheterization and received fetal glucagon (

Indexed as

Amino AcidsFetusGlucagonLiverAnimalsBlood GlucoseFemaleGluconeogenesisInsulinPlacentaPregnancyReceptors, GlucagonSheepAmino AcidsBlood GlucoseGlucagonInsulinReceptors, Glucagonamino acidsfetusglucagongluconeogenesisliver

Identifiers

PMID40076531
PMCPMC11900341

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.