Evidence map›Paper›PMID 40076518›Full record

ArticleInternational journal of molecular sciences2025

Peptide Fractions Extracted from the Hemolymph of

Donatella Lucchetti, Roberta Rinaldi, Giulia Artemi, Rosanna Salvia, Federica De Stefano, Carmen Scieuzo, Patrizia Falabella, Alessandro Sgambato

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Donatella LucchettiDepartment of Translational Medicine and Surgery, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.
Roberta RinaldiDepartment of Basic and Applied Sciences, University of Basilicata, Via dell'Ateneo Lucano 10, 85100 Potenza, Italy.ORCID 0000-0001-8364-8387
Giulia ArtemiDepartment of Translational Medicine and Surgery, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.
Rosanna SalviaDepartment of Basic and Applied Sciences, University of Basilicata, Via dell'Ateneo Lucano 10, 85100 Potenza, Italy.ORCID 0000-0002-6661-7164
Federica De StefanoDepartment of Basic and Applied Sciences, University of Basilicata, Via dell'Ateneo Lucano 10, 85100 Potenza, Italy.ORCID 0009-0008-8463-3345
Carmen ScieuzoDepartment of Basic and Applied Sciences, University of Basilicata, Via dell'Ateneo Lucano 10, 85100 Potenza, Italy.ORCID 0000-0001-5540-0712
Patrizia FalabellaDepartment of Basic and Applied Sciences, University of Basilicata, Via dell'Ateneo Lucano 10, 85100 Potenza, Italy.ORCID 0000-0003-0304-6867
Alessandro SgambatoDepartment of Translational Medicine and Surgery, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.ORCID 0000-0002-9487-4563

Funding

Ministero dell'università e della ricerca PRIN 2017, Prot. 2017AHTCK7_001
6 · The paper itself

Abstract

Cancer is a leading cause of death worldwide, characterized by uncontrolled cell growth and multiple mutations. Chemotherapy is often associated with harmful side effects, and cancer cells may become resistant through various mechanisms. New approaches, which are able to address both the toxicity and resistance issues of chemotherapy, are of primary importance in cancer research. Antimicrobial peptides (AMPs), naturally occurring molecules in the innate immune system of all living organisms, have a wide spectrum of cytotoxic activities against cancer cells and could be a promising alternative to actual chemotherapeutics. Here, we tested peptide fractions, rich in AMPs, extracted from the hemolymph of the larvae of the insect

Indexed as

Antimicrobial PeptidesAntineoplastic AgentsColorectal NeoplasmsHemolymphPeptidesAnimalsApoptosisCell MovementCell ProliferationHCT116 CellsHT29 CellsHumansInsect ProteinsLarvaAntimicrobial PeptidesAntineoplastic AgentsInsect ProteinsPeptidesanticancer peptidesinsectsin vitro anticancer activity

Identifiers

PMID40076518
PMCPMC11899838

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.