ArticleInternational journal of molecular sciences2025
Sex-Specific Improvements in Myocardial Function and Angiogenesis with SGLT-2 Inhibitor Canagliflozin in a Swine Model of Metabolic Syndrome.
Dwight D Harris, Mark Broadwin, Christopher Stone, Sharif A Sabe, Meghamsh Kanuparthy, Ju-Woo Nho, Kelsey C Muir, M Ruhul Abid, Frank W Sellke
Abstract read
In one paragraphArticle in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
9 authors.
Dwight D HarrisDivision of Cardiothoracic Surgery, Department of Surgery, Cardiovascular Research Center, Alpert Medical School of Brown University, Brown University Health, 2 Dudley Street, MOC 360, Providence, RI 02905, USA.
Mark BroadwinDivision of Cardiothoracic Surgery, Department of Surgery, Cardiovascular Research Center, Alpert Medical School of Brown University, Brown University Health, 2 Dudley Street, MOC 360, Providence, RI 02905, USA.ORCID 0000-0002-0393-9983 Christopher StoneDivision of Cardiothoracic Surgery, Department of Surgery, Cardiovascular Research Center, Alpert Medical School of Brown University, Brown University Health, 2 Dudley Street, MOC 360, Providence, RI 02905, USA.
Sharif A SabeDivision of Cardiothoracic Surgery, Department of Surgery, Cardiovascular Research Center, Alpert Medical School of Brown University, Brown University Health, 2 Dudley Street, MOC 360, Providence, RI 02905, USA.ORCID 0000-0002-8169-6753 Meghamsh KanuparthyDivision of Cardiothoracic Surgery, Department of Surgery, Cardiovascular Research Center, Alpert Medical School of Brown University, Brown University Health, 2 Dudley Street, MOC 360, Providence, RI 02905, USA.ORCID 0009-0005-7581-0555 Ju-Woo NhoDivision of Cardiothoracic Surgery, Department of Surgery, Cardiovascular Research Center, Alpert Medical School of Brown University, Brown University Health, 2 Dudley Street, MOC 360, Providence, RI 02905, USA.ORCID 0009-0006-1260-070X Kelsey C MuirDivision of Cardiothoracic Surgery, Department of Surgery, Cardiovascular Research Center, Alpert Medical School of Brown University, Brown University Health, 2 Dudley Street, MOC 360, Providence, RI 02905, USA.
M Ruhul AbidDivision of Cardiothoracic Surgery, Department of Surgery, Cardiovascular Research Center, Alpert Medical School of Brown University, Brown University Health, 2 Dudley Street, MOC 360, Providence, RI 02905, USA.
Frank W SellkeDivision of Cardiothoracic Surgery, Department of Surgery, Cardiovascular Research Center, Alpert Medical School of Brown University, Brown University Health, 2 Dudley Street, MOC 360, Providence, RI 02905, USA.ORCID 0000-0002-8886-801X Funding
Uncoupling of IL-1 beta and VEGF-A Crosstalk Contributes to Impaired Arteriogenesis Response to Ischemia in Chronic Diabetes MellitusP20GM103652 · NIGMS · OCEAN STATE RESEARCH INSTITUTE, INC. · PI YAO, HONGWEI · 2013 to 2022
$21.3MEffect of Cardioplegia and Cardiopulmonary Bypass on Coronary Microvascular ReactivityR01HL046716 · NHLBI · RHODE ISLAND HOSPITAL · PI SELLKE, FRANK W · 1997 to 2023
$8.5MStem Cells and AgingP30GM145500 · NIGMS · RHODE ISLAND HOSPITAL · PI PETER J. QUESENBERRY · 2023 to 2026
$6.0MVascular Dysfunction in Myocardial Ischemia and Metabolic SyndromeR01HL128831 · NHLBI · RHODE ISLAND HOSPITAL · PI SELLKE, FRANK W, USHEVA-SIMIDJIYSKA, ANNY · 2016 to 2025
$5.7MSub-cellular Targeting of Endothelial ROS in Myocardial IschemiaR01HL133624 · NHLBI · RHODE ISLAND HOSPITAL · PI ABID, RUHUL · 2017 to 2020
$1.6MCardiovascular Surgery Research TrainingT32HL160517 · NHLBI · RHODE ISLAND HOSPITAL · PI Frank W Sellke · 2022 to 2026
$1.5MSub-cellular Targeting of Endothelial ROS in Myocardial IschemiaR56HL133624 · NHLBI · RHODE ISLAND HOSPITAL · PI ABID, RUHUL · 2022 to 2022
$613kImpact of Glycemic Control on Extracellular Vesicle-Mediated Angiogenesis in a Porcine Model of Chronic Myocardial Ischemia and Metabolic SyndromeF32HL160063 · NHLBI · RHODE ISLAND HOSPITAL · PI SABE, SHARIF A. · 2021 to 2022
$149kNHLBI NIH HHS F32 HL160063NHLBI NIH HHS R01 HL046716NHLBI NIH HHS R01 HL128831NHLBI NIH HHS R01 HL133624NHLBI NIH HHS R56 HL133624NHLBI NIH HHS T32 HL160517NIGMS NIH HHS P20 GM103652NIGMS NIH HHS P30 GM145500NIH HHS R01HL128831
6 · The paper itselfAbstract
There is a significant body of literature to suggest that coronary artery disease (CAD) is a highly sex-specific disease. The study of sex-specific therapeutics and sex-specific responses to treatment for CAD remains underreported in the literature. Sodium-glucose transporter 2 (SGLT2) inhibitors are of growing interest in the treatment of ischemic heart disease and heart failure; however, the sex-specific response to SGLT2 inhibitors is unknown. We studied an SGLT2 inhibitor, canagliflozin, in a swine model of metabolic syndrome (MS) and chronic myocardial ischemia with emphasis on the sex-specific outcomes. Yorkshire swine (
Indexed as
CanagliflozinHeartMetabolic SyndromeNeovascularization, PhysiologicSodium-Glucose Transporter 2 InhibitorsAngiogenesisAnimalsDisease Models, AnimalFemaleMaleMyocardial IschemiaMyocardiumSex FactorsSwineCanagliflozinSodium-Glucose Transporter 2 Inhibitorsameroid constrictorcanagliflozinchronic myocardial ischemiafemalemalemetabolic syndromesexsodium-glucose cotransporter-2 inhibitor
Identifiers
PMID40076513
PMCPMC11900068
What OpenQuestion holds
Texttitle and abstract
LicenceCC BY
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