ReviewInternational journal of molecular sciences2025
Lubrication for Osteoarthritis: From Single-Function to Multifunctional Lubricants.
Review in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Intra-articular injections for shoulder arthritis in adults: a systematic review.European journal of medical research · 2025Pooled it
- Engineered Injectable Hydrogel Platform for Tailoring the Osteoarthritis Microenvironment.Advanced healthcare materials · 2026Review
- Hydrogels as Local Structural-Protective Platforms in Rheumatoid Arthritis: An Evidence-Graded Review Across the Synovium-Cartilage-Bone Axis.Gels (Basel, Switzerland) · 2026Review
- The Preparation and Evaluation of Carvacrol-Added Hyaluronic Acid for Early Osteoarthritis Treatment.Antioxidants (Basel, Switzerland) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Osteoarthritis (OA) is a common degenerative joint disease that progressively destroys articular cartilage, leading to increased joint friction and severe pain. Therefore, OA can be treated by restoring the lubricating properties of cartilage. In this study, recent advances in lubricants for the treatment of OA are reviewed for both single-function and multifunctional lubricants. Single-function lubricants mainly include glycosaminoglycans, lubricin, and phospholipids, whereas multifunctional lubricants are composed of lubricating and anti-inflammatory bifunctional hydrogels, stem cell-loaded lubricating hydrogels, and drug-loaded lubricating nanoparticles. This review emphasizes the importance of restoring joint lubrication capacity for the treatment of OA and explores the structural features, lubrication properties, and role of these lubricants in modulating intracellular inflammatory responses and metabolism. Current challenges and future research directions in this field are also discussed, with the aim of providing a scientific basis and new ideas for the clinical treatment of OA.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.