Evidence map›Paper›PMID 40076453›Full record

ArticleInternational journal of molecular sciences2025

Purinergic System Transcript Changes in the Dorsolateral Prefrontal Cortex in Suicide and Major Depressive Disorder.

Smita Sahay, Anna E Lundh, Roshan P Sirole, Robert E McCullumsmith, Sinead M O'Donovan

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Smita SahayDepartment of Neurosciences and Psychiatry, University of Toledo College of Medicine and Life Sciences, Toledo, OH 43614, USA.ORCID 0009-0003-4377-8963
Anna E LundhDepartment of Neurosciences and Psychiatry, University of Toledo College of Medicine and Life Sciences, Toledo, OH 43614, USA.
Roshan P SiroleDepartment of Neurosciences and Psychiatry, University of Toledo College of Medicine and Life Sciences, Toledo, OH 43614, USA.
Robert E McCullumsmithDepartment of Neurosciences and Psychiatry, University of Toledo College of Medicine and Life Sciences, Toledo, OH 43614, USA.ORCID 0000-0001-6921-7150
Sinead M O'DonovanDepartment of Neurosciences and Psychiatry, University of Toledo College of Medicine and Life Sciences, Toledo, OH 43614, USA.ORCID 0000-0003-3172-4952

Funding

Cell-specific analysis of sub-kinomes in schizophreniaR01MH107487 · NIMH · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI MCCULLUMSMITH, ROBERT E, MELLER, JAREK · 2016 to 2020
$1.9M
American Foundation of Suicide Prevention YIG-1-139-20NIMH NIH HHS MH107487NIMH NIH HHS R01 MH107487
6 · The paper itself

Abstract

Suicide is a major public health priority, and its molecular mechanisms appear to be related to imbalanced purine metabolism in the brain. This exploratory study investigates purinergic gene expression in the postmortem dorsolateral prefrontal cortex (DLPFC) tissue isolated from subjects with major depressive disorder (MDD) who died by suicide (MDD-S,

Indexed as

Dorsolateral Prefrontal CortexMajor Depressive DisorderPrefrontal CortexReceptors, PurinergicSuicideAdultAgedFemaleGray MatterHumansMaleMiddle AgedRNA, MessengerWhite MatterReceptors, PurinergicRNA, Messengercortical layersdorsolateral prefrontal cortexmajor depressive disorderpostmortempurinergic systemsuicidetranscript

Identifiers

PMID40076453
PMCPMC11898938

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.