Evidence map›Paper›PMID 40076435›Full record

ArticleInternational journal of molecular sciences2025

Protocatechualdehyde Induced Breast Cancer Stem Cell Death via the Akt/Sox2 Signaling Pathway.

Seung-Yeon Ko, Seonghee Park, Youn-Hee Choi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Seung-Yeon KoDepartment of Physiology, College of Medicine, Ewha Womans University, Seoul 07804, Republic of Korea.
Seonghee ParkDepartment of Physiology, College of Medicine, Ewha Womans University, Seoul 07804, Republic of Korea.ORCID 0009-0002-8873-8159
Youn-Hee ChoiDepartment of Physiology, College of Medicine, Ewha Womans University, Seoul 07804, Republic of Korea.ORCID 0000-0002-7971-9493

Funding

National Research Foundation of Korea NRF-2020R1A5A2019210433
6 · The paper itself

Abstract

Breast cancer (BC) is most frequently recognized in women and characterized by histological and molecular heterogeneity. Among the various subtypes, triple-negative BC remains the most challenging disease owing to the lack of effective molecular targets and the high frequency of breast cancer stem cells (BCSCs), which account for both recurrence and resistance to conventional treatments. Despite the availability of hormonal therapies and targeted treatments, patients still face early and late relapses, necessitating new cytotoxic and selective treatment strategies. Our study focuses on investigating the effects of protocatechualdehyde (PCA), a potent bioactive compound derived from

Indexed as

BenzaldehydesBreast NeoplasmsCatecholsNeoplastic Stem CellsProto-Oncogene Proteins c-aktSignal TransductionSOXB1 Transcription FactorsAnimalsCell DeathCell Line, TumorCell ProliferationFemaleHumansMiceMice, Inbred BALB CBenzaldehydesCatecholsprotocatechualdehydeProto-Oncogene Proteins c-aktSOX2 protein, humanSOXB1 Transcription FactorsAktALDH1Abreast cancercancer stem cellprotocatechualdehydeSox2

Identifiers

PMID40076435
PMCPMC11899452

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.