Evidence map›Paper›PMID 40076408›Full record

ArticleMolecules (Basel, Switzerland)2025

Forsythiaside A Reduces Acetaminophen Hepatotoxic Metabolism by Inhibiting Pregnane X Receptor.

Sisi Pu, Yangyang Pan, Zuoyang Wang, Huimin Liu, Jianhui Zhang, Qian Zhang, Meng Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Mechanisms and Therapeutic Advances of PXR in Metabolic Diseases and Cancer.International journal of molecular sciences · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sisi PuCollege of Veterinary Medicine, Gansu Agricultural University, Lanzhou 730070, China.
Yangyang PanCollege of Veterinary Medicine, Gansu Agricultural University, Lanzhou 730070, China.
Zuoyang WangCollege of Veterinary Medicine, Gansu Agricultural University, Lanzhou 730070, China.
Huimin LiuCollege of Veterinary Medicine, Gansu Agricultural University, Lanzhou 730070, China.
Jianhui ZhangCollege of Veterinary Medicine, Gansu Agricultural University, Lanzhou 730070, China.
Qian ZhangCollege of Veterinary Medicine, Gansu Agricultural University, Lanzhou 730070, China.
Meng WangCollege of Veterinary Medicine, Gansu Agricultural University, Lanzhou 730070, China.

Funding

The National Natural Science Foundation of China 32160850
6 · The paper itself

Abstract

Overdose intake of acetaminophen (APAP) causes liver injury involving hepatic drug metabolism and activation of oxidative stress pathways, and forsythiaside A (FA) has hepatoprotective pharmacological activity, but knowledge of the mechanism of FA treatment for APAP liver injury is still lacking the literature. In this study, we investigated the effects of FA on the pregnane X receptor (

Indexed as

AcetaminophenChemical and Drug Induced Liver InjuryGlycosidesPregnane X ReceptorAnimalsApoptosisCytochrome P-450 CYP3AEndoplasmic Reticulum StressHumansLiverMaleMiceMolecular Docking SimulationOxidative StressAcetaminophenCytochrome P-450 CYP3AforsythiasideGlycosidesPregnane X Receptoracetaminophen metabolismapoptosisendoplasmic reticulum stressforsythiaside Aoxidative stresspregnane X receptor

Identifiers

PMID40076408
PMCPMC11902173

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.